ArticleJournal of immunology (Baltimore, Md. : 1950)2008
Plasmodium infection and endotoxic shock induce the expansion of regulatory dendritic cells.
Article in Journal of immunology (Baltimore, Md. : 1950), 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Intestinal luminal anion transporters and their interplay with gut microbiome and inflammation.American journal of physiology. Cell physiology · 2025Review
- Type I interferons drive inflammasome-independent emergency monocytopoiesis during endotoxemia.Scientific reports · 2017Article
- Splenic CD11c(low)CD45RB(high) dendritic cells derived from endotoxin-tolerant mice attenuate experimental acute liver failure.Scientific reports · 2016Article
- Dendritic Cells and Their Multiple Roles during Malaria Infection.Journal of immunology research · 2016Review
- Endotoxic shock-expanded murine CD11c low CD45RB + regulatory dendritic cells modulate inflammatory T cell responses through multiple mechanisms.Scientific reports · 2015Article
- The Regulation of CD4(+) T Cell Responses during Protozoan Infections.Frontiers in immunology · 2014Review
- Regulation of immunopathogenesis during Plasmodium and Toxoplasma infections: more parallels than distinctions?Trends in parasitology · 2013Review
- Modulating intestinal immune responses by lipoteichoic acid-deficient Lactobacillus acidophilus.Immunotherapy · 2012Article
- Chronic helminth infection promotes immune regulation in vivo through dominance of CD11cloCD103- dendritic cells.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Regulating the adaptive immune response to blood-stage malaria: role of dendritic cells and CD4⁺Foxp3⁺ regulatory T cells.International journal of biological sciences · 2011Review
- Mechanisms underlying the induction of regulatory T cells and its relevance in the adaptive immune response in parasitic infections.International journal of biological sciences · 2011Review
- Dual effect of Plasmodium-infected erythrocytes on dendritic cell maturation.Malaria journal · 2010Article
- Modulation of dendritic cell responses by parasites: a common strategy to survive.Journal of biomedicine & biotechnology · 2010Review
- The role of CD40 and CD154/CD40L in dendritic cells.Seminars in immunology · 2009Review
- Dendritic cell and NK cell reciprocal cross talk promotes gamma interferon-dependent immunity to blood-stage Plasmodium chabaudi AS infection in mice.Infection and immunity · 2009Article
- A Plasmodium yoelii soluble factor inhibits the phenotypic maturation of dendritic cells.Malaria journal · 2008Article
- What really happens to dendritic cells during malaria?Nature reviews. Microbiology · 2008Review
- Role of endogenous and induced regulatory T cells during infections.Journal of clinical immunology · 2008Review
- Dendritic cells as immune regulators: the mouse model.Journal of cellular and molecular medicine · 2008Review
- Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
During an acute Plasmodium infection, uncontrolled proinflammatory responses can cause morbidity and mortality. Regulation of this response is required to prevent immunopathology. We therefore decided to investigate a recently characterized subset of regulatory dendritic cells (DCs) that expresses low levels of CD11c and high levels of CD45RB. During a Plasmodium yoelii infection, these regulatory CD11clowCD45RBhigh DCs become the prevalent CD11c-expressing cells in the spleen, overtaking the conventional CD11chigh DCs. Furthermore, the regulatory CD11clowCD45RBhigh DCs induce IL-10-expressing CD4 T cells. A similar change in splenic DC subsets is seen when mice are injected with sublethal doses of LPS, suggesting that shifting the splenic DC subsets in favor of regulatory CD11clowCD45RBhigh DCs can be triggered solely by a high inflammatory stimulus. This is the first time regulatory DCs have been observed in a natural immune response to an infectious disease or endotoxic shock.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.