ArticleBiophysical journal2008
A physical model of axonal elongation: force, viscosity, and adhesions govern the mode of outgrowth.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 115 citations in OpenAlex.
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.bioRxiv : the preprint server for biology · 2024Article
- A simple active fluid model unites cytokinesis, cell crawling, and axonal outgrowth.Frontiers in cell and developmental biology · 2024Article
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Magnetically-actuated microposts stimulate axon growth.Biophysical journal · 2022Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- Extremely Low Forces Induce Extreme Axon Growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing.Biophysical journal · 2020Article
- Effect of Cyclic Stretch on Neuron Reorientation and Axon Outgrowth.Frontiers in bioengineering and biotechnology · 2020Article
- Axonal cytomechanics in neuronal development.Journal of biosciences · 2020Review
- A computational model of bidirectional axonal growth in micro-tissue engineered neuronal networks (micro-TENNs).In silico biology · 2020Article
- The model of local axon homeostasis - explaining the role and regulation of microtubule bundles in axon maintenance and pathology.Neural development · 2019Review
- Tension- and Adhesion-Regulated Retraction of Injured Axons.Biophysical journal · 2019Article
- Challenges and demand for modeling disorders of consciousness following traumatic brain injury.Neuroscience and biobehavioral reviews · 2019Review
- Piconewton Mechanical Forces Promote Neurite Growth.Biophysical journal · 2018Article
- Modeling the Axon as an Active Partner with the Growth Cone in Axonal Elongation.Biophysical journal · 2018Article
- Theoretical Models of Neural Development.iScience · 2018Review
- Cytoskeletal Mechanisms of Axonal Contractility.Biophysical journal · 2018Article
- Microtubule Polymerization and Cross-Link Dynamics Explain Axonal Stiffness and Damage.Biophysical journal · 2018Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whether the axonal framework is stationary or moves is a central debate in cell biology. To better understand this problem, we developed a mathematical model that incorporates force generation at the growth cone, the viscoelastic properties of the axon, and adhesions between the axon and substrate. Using force-calibrated needles to apply and measure forces at the growth cone, we used docked mitochondria as markers to monitor movement of the axonal framework. We found coherent axonal transport that decreased away from the growth cone. Based on the velocity profiles of movement and the force applied at the growth cone, and by varying the attachment of the axonal shaft to the coverslip, we estimate values for the axial viscosity of the axon (3 x 10(6) +/- 2.4 x 10(6) Pa.s) and the friction coefficient for laminin/polyornithine-based adhesions along the axon (9.6 x 10(3) +/- 7.5 x 10(3) Pa.s). Our model suggests that whether axons elongate by tip growth or stretching depends on the level of force generation at the growth cone, the viscosity of the axon, and the level of adhesions along the axon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.