ArticleBiophysical journal2008
Quantitative determination of size and shape of surface-bound DNA using an acoustic wave sensor.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 129 citations in OpenAlex.
- Quantifying and Controlling DNA Probe Density on the Surface of Silicon Nitride Optical Waveguides.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Swelling Degree of Polyelectrolyte Layers Determined by an Electrochemical Quartz Crystal Microbalance.Biomacromolecules · 2025Article
- Degradation of Sub-Micrometer Sensitive Polymer Layers of Acoustic Sensors Exposed to Chlorpyrifos Water-Solution.Sensors (Basel, Switzerland) · 2022Article
- Quartz crystal microbalance and atomic force microscopy to characterize mimetic systems based on supported lipids bilayer.Frontiers in molecular biosciences · 2022Review
- Acoustic Biosensors and Microfluidic Devices in the Decennium: Principles and Applications.Micromachines · 2021Review
- Hybrid Sensor Device for Simultaneous Surface Plasmon Resonance and Surface Acoustic Wave Measurements.Sensors (Basel, Switzerland) · 2020Article
- A force sensor that converts fluorescence signal into force measurement utilizing short looped DNA.Biosensors & bioelectronics · 2018Article
- Article
- Acoustic detection of DNA conformation in genetic assays combined with PCR.Scientific reports · 2013Article
- Quantification of the effect of glycocalyx condition on membrane receptor interactions using an acoustic wave sensor.European biophysics journal : EBJ · 2011Article
- Interfacial chemistry and the design of solid-phase nucleic acid hybridization assays using immobilized quantum dots as donors in fluorescence resonance energy transfer.Sensors (Basel, Switzerland) · 2011Article
- Measurement of two-dimensional binding constants between cell-bound major histocompatibility complex and immobilized antibodies with an acoustic biosensor.Biophysical journal · 2008Article
- Acoustic physics of surface-attached biochemical species.HFSP journal · 2008Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DNA bending plays a significant role in many biological processes, such as gene regulation, DNA replication, and chromosomal packing. Understanding how such processes take place and how they can, in turn, be regulated by artificial agents for individual oriented therapies is of importance to both biology and medicine. In this work, we describe the application of an acoustic wave device for characterizing the conformation of DNA molecules tethered to the device surface via a biotin-neutravidin interaction. The acoustic energy dissipation per unit mass observed upon DNA binding is directly related to DNA intrinsic viscosity, providing quantitative information on the size and shape of the tethered molecules. The validity of the above approach was verified by showing that the predesigned geometries of model double-stranded and triple-helix DNA molecules could be quantitatively distinguished: the resolution of the acoustic measurements is sufficient to allow discrimination between same size DNA carrying a bent at different positions along the chain. Furthermore, the significance of this analysis to the study of biologically relevant systems is shown during the evaluation of DNA conformational change upon protein (histone) binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.