ArticleBiophysical journal2008
Tensile properties of single desmin intermediate filaments.
Article in Biophysical journal, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Caenorhabditis elegans small heat-shock protein HSP-12.6 has a highly specialized protective function towards muscle thick filaments in vivo.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2026Article
- Intermediate Filaments: Structure-Mechanics Crosstalk.Sub-cellular biochemistry · 2026Review
- Retinal gliosis and phenotypic diversity of intermediate filament induction and remodeling upon acoustic blast overpressure (ABO) exposure to the rat eye.Experimental eye research · 2023Article
- Calpain Regulation and Dysregulation-Its Effects on the Intercalated Disk.International journal of molecular sciences · 2023Review
- Regulation of neurofilament length and transport by a dynamic cycle of phospho-dependent polymer severing and annealing.Molecular biology of the cell · 2023Article
- Nuclear lamins: Structure and function in mechanobiology.APL bioengineering · 2022Review
- Bend, Push, Stretch: Remarkable Structure and Mechanics of Single Intermediate Filaments and Meshworks.Cells · 2021Review
- Review
- Nuclear Mechanotransduction in Skeletal Muscle.Cells · 2021Review
- Biomechanical Properties of the Sarcolemma and Costameres of Skeletal Muscle Lacking Desmin.Frontiers in physiology · 2021Article
- Stimulation of neural stem cell differentiation by circularly polarized light transduced by chiral nanoassemblies.Nature biomedical engineering · 2021Article
- Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina.Nature communications · 2020Article
- Nuclear filaments: role in chromosomal positioning and gene expression.Nucleus (Austin, Tex.) · 2020Review
- Growing Old Too Early: Skeletal Muscle Single Fiber Biomechanics in Ageing R349P Desmin Knock-in Mice Using theInternational journal of molecular sciences · 2020Article
- Scaling up single-cell mechanics to multicellular tissues - the role of the intermediate filament-desmosome network.Journal of cell science · 2020Review
- Review
- When Stiffness Matters: Mechanosensing in Heart Development and Disease.Frontiers in cell and developmental biology · 2020Review
- The MyoRobot technology discloses a premature biomechanical decay of skeletal muscle fiber bundles derived from R349P desminopathy mice.Scientific reports · 2019Article
- A tensile trilayered cytoskeletal endotube drives capillary-like lumenogenesis.The Journal of cell biology · 2019Article
- Viscoelastic properties of vimentin originate from nonequilibrium conformational changes.Science advances · 2018Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Within muscle fibers, desmin intermediate filaments (IFs) are major constituents of the extrasarcomeric cytoskeleton. However, their contribution to the mechanical properties of myocytes has remained elusive. We present an experimental approach to measure the extensibility and the tensile strength of in vitro reconstituted desmin IFs adsorbed to a solid support. The tip of an atomic force microscope (AFM) was used to push on single filaments perpendicular to the filament axis. The torque of the AFM cantilever was monitored during the pushing events to yield an estimate of the lateral force necessary to bend and stretch the filaments. Desmin IFs were stretched up to 3.4-fold with a maximum force of approximately 3.5 nN. Fully stretched filaments exhibited a much smaller diameter than did native IFs, i.e., approximately 3.5 nm compared to 12.6 nm, both by AFM and electron microscopy. Moreover, we combined the morphological and lateral force data to compute an average stress-strain curve for a single desmin filament. The main features were a pronounced strain-hardening regime above 50% extension and a tensile strength of at least 240 MPa. Because of these nonlinear tensile properties, desmin IFs may dissipate mechanical energy and serve as a physical link between successive sarcomeres during large deformation.
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