ArticleGeneral and comparative endocrinology2008
Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasing hormone-like molecule in the gastropod mollusk, Aplysia californica.
Article in General and comparative endocrinology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 107 citations in OpenAlex.
- Evaluation of the Effect of Adipokinetic Hormone/Corazonin-Related Peptide (ACP) on Ovarian Development in the Mud Crab,Animals : an open access journal from MDPI · 2024Article
- Identification and characterization of gonadotropin-releasing hormone (GnRH) in Zhikong scallopFrontiers in physiology · 2023Article
- Identification and localization of a gonadotropin-releasing hormone-related neuropeptide in Biomphalaria, an intermediate host for schistosomiasis.The Journal of comparative neurology · 2021Article
- Functional characterization and related evolutionary implications of invertebrate gonadotropin-releasing hormone/corazonin in a well-established model species.Scientific reports · 2021Article
- Identification and Characterization of Neuropeptides by Transcriptome and Proteome Analyses in a Bivalve MolluscFrontiers in genetics · 2018Article
- Article
- Characterisation of Reproduction-Associated Genes and Peptides in the Pest Land Snail, Theba pisana.PloS one · 2016Article
- Neuropeptides encoded by the genomes of the Akoya pearl oyster Pinctata fucata and Pacific oyster Crassostrea gigas: a bioinformatic and peptidomic survey.BMC genomics · 2014Article
- Localization and functional characterization of a novel adipokinetic hormone in the mollusk, Aplysia californica.PloS one · 2014Article
- Hypothalamic-pituitary-gonadal endocrine system in the hagfish.Frontiers in endocrinology · 2013Review
- Insight from the lamprey genome: glimpsing early vertebrate development via neuroendocrine-associated genes and shared synteny of gonadotropin-releasing hormone (GnRH).General and comparative endocrinology · 2013Article
- Nervous control of reproduction in Octopus vulgaris: a new model.Invertebrate neuroscience : IN · 2013Review
- Pheromonal bile acid 3-ketopetromyzonol sulfate primes the neuroendocrine system in sea lamprey.BMC neuroscience · 2013Article
- Evolution of vertebrate GnRH receptors from the perspective of a Basal vertebrate.Frontiers in endocrinology · 2012Article
- A gonadotropin-releasing hormone-like molecule modulates the activity of diverse central neurons in a gastropod mollusk, aplysia californica.Frontiers in endocrinology · 2011Article
- Evolutionary origin of a functional gonadotropin in the pituitary of the most primitive vertebrate, hagfish.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Environmental-endocrine control of reproductive maturation in gastropods: implications for the mechanism of tributyltin-induced imposex in prosobranchs.Ecotoxicology (London, England) · 2010Article
- Origins of gonadotropin-releasing hormone (GnRH) in vertebrates: identification of a novel GnRH in a basal vertebrate, the sea lamprey.Endocrinology · 2008Article
- The identification and distribution of gonadotropin-releasing hormone-like peptides in the central nervous system and ovary of the giant freshwater prawn, Macrobrachium rosenbergii.Invertebrate neuroscience : IN · 2008Article
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
Abstract
Successful reproduction in vertebrates depends upon the actions of gonadotropin-releasing hormone (GnRH). Despite the wide presence of GnRH in Phylum Chordata, GnRH has not been isolated in protostomes other than the common octopus. To provide information on the evolution of this critical hormone, we isolated the full-length cDNA of a GnRH-like molecule from the central nervous system of a gastropod mollusk, the sea hare Aplysia californica. The open reading frame of this cDNA encodes a protein of 147 amino acids. The molecular architecture of the deduced protein is highly homologous to that reported for the prepro-octopus GnRH (oct-GnRH) and consists of a putative signal peptide, a GnRH dodecapeptide, a downstream processing site, and a GnRH-associated peptide (GAP). The deduced amino acid sequence of the Aplysia GnRH (ap-GnRH) is QNYHFSNGWYAG and differs from oct-GnRH by only two amino acids. The transcript for ap-GnRH is widely expressed in the central nervous system (CNS), the ovotestis, and the atrial gland, an exocrine gland. Immunocytochemistry (ICC) using an antiserum against oct-GnRH detected immunoreactive neurons in all CNS ganglia examined, and the staining was abolished by the preadsorption of the antiserum with synthetic ap-GnRH. In sum, ap-GnRH sequence is the first gastropod GnRH-like molecule to be elucidated. Further, it represents one of the only two GnRH-like molecules found outside Phylum Chordata. These data refute the possibility that oct-GnRH arose singly in cephalopods by convergent evolution and provide valuable support for an ancient origin of GnRH during metazoan evolution.
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