ArticleDevelopmental and comparative immunology2008
Cathepsin L and cystatin B gene expression discriminates immune coelomic cells in the leech Theromyzon tessulatum.
Article in Developmental and comparative immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 25 citations in OpenAlex.
- Revealing the Immune Response ofInsects · 2024Article
- Heterologous Production and Evaluation of the Biological Activity of Cystatin-B From the Red PiranhaFrontiers in genetics · 2022Article
- Novel Cysteine Protease Inhibitor Derived from theToxins · 2021Article
- Article
- A novel type I cystatin of parasite origin with atypical legumain-binding domain.Scientific reports · 2017Article
- Colonization state influences the hemocyte proteome in a beneficial squid-Vibrio symbiosis.Molecular & cellular proteomics : MCP · 2014Article
- Cathepsin L in the orange-spotted grouper, Epinephelus coioides: molecular cloning and gene expression after a Vibrio anguillarum challenge.Fish physiology and biochemistry · 2012Article
- Morphological and functional characterization of leech circulating blood cells: role in immunity and neural repair.Cellular and molecular life sciences : CMLS · 2012Article
- Bacterial feeding induces changes in immune-related gene expression and has trans-generational impacts in the cabbage looper (Trichoplusia ni).Frontiers in zoology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Previous studies evidenced that cystatin B-like gene is specifically expressed and induced in large circulating coelomic cells following bacterial challenge in the leech Theromyzon tessulatum. In order to understand the role of that cysteine proteinase inhibitor during immune response, we investigated the existence of members of cathepsin family. We cloned a cathepsin L-like gene and studied its tissue distribution. Immunohistochemical studies using anti-cathepsin L and anti-cystatin B antibodies and ultrastructural results demonstrated the presence of three distinct coelomic cell populations: (1) the chloragocytes, which were initially defined as large coelomocytes, (2) the granular amoebocytes and (3) small coelomic cells. Among those cells, while chloragocytes contain cystatin B and cathepsin L, granular amoebocytes contain only cathepsin L and the third cell population contains neither cathepsin nor inhibitor. Finally, results evidenced that cathepsin L immunopositive granular amoebocytes are chemoattracted to the site of injury and phagocyte bacteria.
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