ArticleCell metabolism2008
Interferon regulatory factors are transcriptional regulators of adipogenesis.
Article in Cell metabolism, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 85 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
85 citing papers in PubMed, 136 citations in OpenAlex.
- Reduced glycoprotein hormone β5 links male aging and testosterone decline to increased adiposity.The Journal of clinical investigation · 2026Article
- Comparative single-cell lineage tracing identifies distinct adipocyte precursor dynamics in skin and inguinal fat.Cell stem cell · 2025Article
- Brown and beige adipose tissue-derived metabokine and lipokine inter-organ signalling in health and disease.Experimental physiology · 2025Review
- The diverse interaction of metabolism, immune response, and viral pathogens.Frontiers in immunology · 2025Review
- Transcriptional control of metabolism by interferon regulatory factors.Nature reviews. Endocrinology · 2024Review
- Detecting anomalous anatomic regions in spatial transcriptomics with STANDS.Nature communications · 2024Article
- Inflammation causes insulin resistance in mice via interferon regulatory factor 3 (IRF3)-mediated reduction in FAHFA levels.Nature communications · 2024Article
- Impaired BCAA catabolism in adipose tissues promotes age-associated metabolic derangement.Nature aging · 2023Article
- The crosstalk between BAT thermogenesis and skeletal muscle dysfunction.Frontiers in physiology · 2023Review
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- Unique role for lncRNA HOTAIR in defining depot-specific gene expression patterns in human adipose-derived stem cells.Genes & development · 2022Article
- Consistent downregulation of the cleft lip/palate-associated genesFrontiers in oncology · 2022Article
- Regulation of adipogenic differentiation and adipose tissue inflammation by interferon regulatory factor 3.Cell death and differentiation · 2021Article
- Single cell functional genomics reveals plasticity of subcutaneous white adipose tissue (WAT) during early postnatal development.Molecular metabolism · 2021Article
- A BAFF/APRIL axis regulates obesogenic diet-driven weight gain.Nature communications · 2021Article
- Implications of metabolism-driven myeloid dysfunctions in cancer therapy.Cellular & molecular immunology · 2021Review
- IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis.The Journal of clinical investigation · 2021Article
- Evolution of the IRF Family in Salmonids.Genes · 2021Article
- Adipocyte-Specific Ablation of PU.1 Promotes Energy Expenditure and Ameliorates Metabolic Syndrome in Aging Mice.Frontiers in aging · 2021Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
We have sought to identify transcriptional pathways in adipogenesis using an integrated experimental and computational approach. Here, we employ high-throughput DNase hypersensitivity analysis to find regions of altered chromatin structure surrounding key adipocyte genes. Regions that display differentiation-dependent changes in hypersensitivity were used to predict binding sites for proteins involved in adipogenesis. A high-scoring example was a binding motif for interferon regulatory factor (IRF) family members. Expression of all nine mammalian IRF mRNAs is regulated during adipogenesis, and several bind to the identified motifs in a differentiation-dependent manner. Furthermore, several IRF proteins repress differentiation. This analysis suggests an important role for IRF proteins in adipocyte biology and demonstrates the utility of this approach in identifying cis- and trans-acting factors not previously suspected to participate in adipogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.