ArticleBMC neuroscience2008
A novel site of adult doublecortin expression: neuropeptide neurons within the suprachiasmatic nucleus circadian clock.
Article in BMC neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Meta-Analysis Characterizing Stem-Like Gene Expression in the Suprachiasmatic Nucleus and Its Circadian Clock.BioMed research international · 2018Pooled it
- Review
- Sleep-wake cycle disturbances and NeuN-altered expression in adult rats after cannabidiol treatments during adolescence.Psychopharmacology · 2021Article
- The Cell-Autonomous Clock of VIP Receptor VPAC2 Cells Regulates Period and Coherence of Circadian Behavior.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- The retinoid X receptor: a nuclear receptor that modulates the sleep-wake cycle in rats.Psychopharmacology · 2020Article
- Novel Rbfox2 isoforms associated with alternative exon usage in rat cortex and suprachiasmatic nucleus.Scientific reports · 2017Article
- Collective timekeeping among cells of the master circadian clock.The Journal of endocrinology · 2016Review
- Persistent neuronal Ube3a expression in the suprachiasmatic nucleus of Angelman syndrome model mice.Scientific reports · 2016Article
- Constructing the suprachiasmatic nucleus: a watchmaker's perspective on the central clockworks.Frontiers in systems neuroscience · 2015Review
- Chronic fluoxetine increases extra-hippocampal neurogenesis in adult mice.The international journal of neuropsychopharmacology · 2014Article
- Neuroanatomy of the extended circadian rhythm system.Experimental neurology · 2013Review
- Postnatal administration of IL-1Ra exerts neuroprotective effects following perinatal inflammation and/or hypoxic-ischemic injuries.Brain, behavior, and immunity · 2012Article
- Repeated PTZ treatment at 25-day intervals leads to a highly efficient accumulation of doublecortin in the dorsal hippocampus of rats.PloS one · 2012Article
- Neurons identified by NeuN/Fox-3 immunoreactivity have a novel distribution in the hamster and mouse suprachiasmatic nucleus.Brain research · 2011Article
- Transcription Mapping of Embryonic Rat Brain Reveals EGR-1 Induction in SOX2 Neural Progenitor Cells.Frontiers in molecular neuroscience · 2011Article
- Time of day differences in the number of cytokine-, neurotrophin- and NeuN-immunoreactive cells in the rat somatosensory or visual cortex.Brain research · 2010Article
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2 authors at 1 institution in 1 country.
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Abstract
backgroundThe mammalian suprachiasmatic nucleus (SCN) is composed of heterogeneous sub-groups of neurons that are organized into a neural system for the control of circadian physiology and behaviour. Molecular circadian 'clocks' are not an exclusive property of SCN neurons but the unique role of the SCN as a central integrative pacemaker is associated with specialized aspects of neuronal organization. Current studies are aimed at identifying the functional components of this hypothalamic integrative centre.
resultsIn the present study we have identified and characterized a quite novel aspect of SCN neurobiology, doublecortin (DCX) protein expression within a defined group of adult rat SCN neurons. Adult neuronal DCX expression is surprising because this microtubule-associated protein (MAP) is generally a developmentally restricted component of immature, migrating neurons. We have also demonstrated for the first time that the SCN as a whole exhibits low expression of the neuronal differentiation marker NeuN. However, DCX is co-localized with NeuN in the ventral SCN, and also with neuropeptides; DCX is extensively co-localized with GRP and partially co-localized with VIP.
conclusionThe highly selective expression of DCX in the adult SCN compared with other hypothalamic and thalamic nuclei shows that this MAP is somewhat uniquely required in certain SCN neurons, perhaps contributing to a specific functional property of the brain's circadian clock nucleus. DCX may maintain a capacity for dynamic cellular plasticity that subserves daily alterations in SCN neuronal signalling.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.