SynthesisThe American journal of gastroenterology2008
Early life risk factors that contribute to irritable bowel syndrome in adults: a systematic review.
Synthesis in The American journal of gastroenterology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02613078 (Gut-Directed Hypnotherapy vs. Probiotics in Children and Adolescents With Irritable Bowel Syndrome and Functional Abdominal Pain - A Pilot Study), which is not on this map. Cited by 144 papers, 7 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Gut-Directed Hypnotherapy vs. Probiotics in Children and Adolescents With Irritable Bowel Syndrome and Functional Abdominal Pain - A Pilot Study
Who cites it
144 citing papers in PubMed, 7 syntheses or guidelines pooled it, 296 citations in OpenAlex.
- Risk factors for developing irritable bowel syndrome: systematic umbrella review of reviews.BMC medicine · 2025Pooled it
- Risk Factors for Abdominal Pain-Related Disorders of Gut-Brain Interaction in Adults and Children: A Systematic Review.Gastroenterology · 2022Pooled it
- Acupuncture and related therapies for the anxiety and depression in irritable bowel syndrome with diarrhea (IBS-D): A network meta-analysis of randomized controlled trials.Frontiers in psychiatry · 2022Pooled it
- Parental, Perinatal, and Childhood Risk Factors for Development of Irritable Bowel Syndrome: A Systematic Review.Journal of neurogastroenterology and motility · 2020Pooled it
- Pooled it
- Anxiety and depression comorbidities in irritable bowel syndrome (IBS): a systematic review and meta-analysis.European archives of psychiatry and clinical neuroscience · 2014Pooled it
- Psychological trauma and functional somatic syndromes: a systematic review and meta-analysis.Psychosomatic medicine · 2014Pooled it
- Cost-effectiveness of internet-delivered cognitive-behavioural therapy for adolescents with irritable bowel syndrome.BMJ open · 2019Trial
- Internet-Delivered Cognitive Behavior Therapy for Adolescents With Irritable Bowel Syndrome: A Randomized Controlled Trial.The American journal of gastroenterology · 2017Trial
- I.31, a new combination of probiotics, improves irritable bowel syndrome-related quality of life.World journal of gastroenterology · 2014Trial
- Identifying Prognostic Factors Implicated in Chronic Functional Abdominal Pain in Children: A Systematic Review.Gastroenterology research · 2026Review
- Associations between childhood behavior and current cognitive and emotional function in adults with irritable bowel syndrome-a cross sectional retrospective study.BMC gastroenterology · 2026Observational
- Enteric and Sympathetic Nervous System Pathways Mediate Early Life Stress Effects on Gut Motility and Pain: Mechanistic Findings With Human Correlation.Gastroenterology · 2026Article
- Adverse childhood experiences and gastrointestinal symptoms in US youth: Psychosocial pathways and protective contexts.Journal of pediatric gastroenterology and nutrition · 2026Article
- Impact of different stress paradigms on irritable bowel syndrome: Evidence from clinical and animal studies.The Journal of international medical research · 2026Review
- Patients' Knowledge, Attitudes, and Practices Regarding Non-pharmacological Treatments for Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2026Article
- Independent and Interactive Associations of Encopresis and Attention-Deficit/Hyperactivity Disorder in Children on Emotional-Behavioral Symptoms, Executive Functioning, and Avoidant/Restrictive Food Intake-Related Symptoms.Research on child and adolescent psychopathology · 2026Article
- Multi-omics analysis reveal clinical-gut-brain interactions in female ibs patients with adverse childhood experiences.Biology of sex differences · 2025Article
- Psychological self-efficacy and coping styles as mediators between perceived stress and IBS symptom severity: a cross-sectional study.Annals of medicine and surgery (2012) · 2025Article
- Sexual function, depression, and quality of life in patients with irritable bowel syndrome.BMC gastroenterology · 2025Article
84 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIrritable bowel syndrome (IBS) is a common disorder that occurs in adults. The natural history of symptoms and risk factors that contribute to IBS may begin in childhood. The aim of this systematic review was to determine what early life factors contribute to the development of IBS in adolescents and adults.
methodsA computer-assisted search of the PubMed database from 1966 to 2007 was performed. The selection criteria were: (a) studies conducted in adolescents or adults with IBS that (b) investigate premorbid factors occurring specifically during the childhood period and are (c) associated with the outcomes of symptoms, quality of life, health-care utilization, and interferences with work or disability.
resultsTwenty-five articles met inclusion criteria. The studies were categorized into articles examining the persistence of childhood gastrointestinal symptoms into adulthood, affluent childhood socioeconomic status and adult IBS, infantile and childhood trauma associated with the development of adult IBS, and social learning of illness behavior as predictors of adult IBS.
conclusionPediatricians should be aware of potentially modifiable childhood risk factors and should consider interventions such as early symptom management of recurrent functional abdominal pain with cognitive therapies and parent education about social learning of illness behavior. Early treatment may have a long-term impact. Research examining the effect of affluent childhood socioeconomic status and early childhood trauma in the evolution of functional gastrointestinal disorders may help identify causative factors of IBS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.