Evidence map›Paper›PMID 18177047›Full record

ArticleJournal of the American Chemical Society2008

Molecular engineering of supramolecular scaffold coatings that can reduce static platelet adhesion.

Aryavarta M S Kumar, Sona Sivakova, Justin D Fox, Jennifer E Green, Roger E Marchant, Stuart J Rowan

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
5.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Aryavarta M S KumarCenter for Cardiovascular Biomaterials, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
Sona Sivakova
Justin D Fox
Jennifer E Green
Roger E Marchant
Stuart J Rowan
Case Western Reserve University · US

Funding

MEDICAL SCIENTIST TRAINING PROGRAMT32GM007250 · NIGMS · CASE WESTERN RESERVE UNIVERSITY · PI HUANG, ALEX YEE-CHEN · 1985 to 2023
$33.4M
Clinical and Translational Science Collaborative of ClevelandTL1TR000441 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$2.8M
NEW BIOMEDICAL INTERFACE MATERIALSR01EB002067 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI MARCHANT, ROGER E · 2003 to 2007
$1.6M
Self-Assembled Bis-PNA Monomers As New BiomaterialsR21EB001466 · NIBIB · CASE WESTERN RESERVE UNIVERSITY · PI ROWAN, STUART J · 2003 to 2004
$446k
NCATS NIH HHS TL1 TR000441NIBIB NIH HHS EB-001466NIBIB NIH HHS EB-002067NIBIB NIH HHS R01 EB002067NIBIB NIH HHS R21 EB001466NIGMS NIH HHS T32 GM007250NIGMS NIH HHS T32 GM07250
6 · The paper itself

Abstract

Novel supramolecular coatings that make use of low-molecular weight ditopic monomers with guanine end groups are studied using fluid tapping AFM. These molecules assemble on highly oriented pyrolytic graphite (HOPG) from aqueous solutions to form nanosized banding structures whose sizes can be systematically tuned at the nanoscale by tailoring the molecular structure of the monomers. The nature of the self-assembly in these systems has been studied through a combination of the self-assembly of structural derivatives and molecular modeling. Furthermore, we introduce the concept of using these molecular assemblies as scaffolds to organize functional groups on the surface. As a first demonstration of this concept, scaffold monomers that contain a monomethyl triethyleneglycol branch were used to organize these "functional" units on a HOPG surface. These supramolecular grafted assemblies have been shown to be stable at biologically relevant temperatures and even have the ability to significantly reduce static platelet adhesion.

Indexed as

AbsorptionAmino Acid MotifsBiocompatible MaterialsEthersEthylene GlycolsGraphiteGuanineHumansHydrogen BondingMicroscopy, Atomic ForceModels, MolecularMolecular ConformationPlatelet AdhesivenessPolyethylene GlycolsTemperatureBiocompatible MaterialsEthersEthylene GlycolsGraphiteGuaninePolyethylene Glycolstriethylene glycol

Identifiers

PMID18177047
PMCPMC2536642
OpenAlexW1997411045

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.