ArticleCurrent microbiology2008
QscR acts as an intermediate in gacA-dependent regulation of PCA biosynthesis in Pseudomonas sp. M-18.
Article in Current microbiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- The RNA chaperone Hfq regulates antibiotic biosynthesis in the rhizobacterium Pseudomonas aeruginosa M18.Journal of bacteriology · 2012Article
- Genomic analysis and temperature-dependent transcriptome profiles of the rhizosphere originating strain Pseudomonas aeruginosa M18.BMC genomics · 2011Article
- Plasmid pAMI2 of Paracoccus aminophilus JCM 7686 carries N,N-dimethylformamide degradation-related genes whose expression is activated by a LuxR family regulator.Applied and environmental microbiology · 2010Article
- Temperature-dependent expression of phzM and its regulatory genes lasI and ptsP in rhizosphere isolate Pseudomonas sp. strain M18.Applied and environmental microbiology · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
The qscR gene, encoding a quorum sensing regulator, was cloned and the qscR-null mutant strain M-18Q derived from Pseudomonas sp. M-18 was constructed to study the effect of the qscR gene on biosynthesis of phenazine-1-carboxylic acid (PCA) and pyoluteorin (Plt) in strain M-18. Results showed that the PCA produced in the mutant increased four- to six-fold, while the synthesis of Plt was barely influenced in comparison with the wild type. The results were confirmed by complementation with the qscR gene in trans in strain M-18Q. The negative effect of the qscR gene on PCA production was further confirmed by analysis of beta-galactosidase activities from the translational phzA'-lacZ' fusion. Furthermore, by introducing a qscR-lacZ transcriptional fusion vector to strains M-18, M-18Q, and M-18G, a gacA inactivation mutant in strain M-18, respectively, it was found that beta-galactosidase activity in both strain M-18G and strain M-18Q was decreased to half that in the wild type. This suggested that QscR might be involved in autoinducing its own gene expression and act as an intermediate in GacA-dependent gene regulation as well. The result was further demonstrated by the overexpression of the gacA gene in strain M-18Q.
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