ArticleEuropean journal of clinical pharmacology2008
Adherence to statin therapy and patients' cardiovascular risk: a pharmacoepidemiological study in Italy.
Article in European journal of clinical pharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 39 citations in OpenAlex.
- Evaluating an implementation strategy in cardiovascular prevention to improve prescribing of statins in Germany: an intention to treat analysis.BMC public health · 2013Trial
- Systematic Review of RCTs Assessing the Effectiveness of mHealth Interventions to Improve Statin Medication Adherence: Using the Behaviour-Change Technique Taxonomy to Identify the Techniques That Improve Adherence.Healthcare (Basel, Switzerland) · 2021Review
- Mitophagy protects against statin-mediated skeletal muscle toxicity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Sense of Coherence is associated with LDL-cholesterol in patients with type 1 diabetes - The PROLONG-Steno study.Journal of clinical & translational endocrinology · 2017Article
- Reasons for (non)compliance with intervention following identification of 'high-risk' status in the NHS Health Check programme.Journal of public health (Oxford, England) · 2015Article
- The impact of regional co-payment and national reimbursement criteria on statins use in Italy: an interrupted time-series analysis.BMC health services research · 2014Article
- Adherence to preventive statin therapy according to socioeconomic position.European journal of clinical pharmacology · 2013Article
- Changes in adherence to statins and subsequent lipid profiles during and following breast cancer treatment.Breast cancer research and treatment · 2013Article
- Article
- Adherence with statins in a real-life setting is better when associated cardiovascular risk factors increase: a cohort study.BMC cardiovascular disorders · 2011Article
- Medication adherence: WHO cares?Mayo Clinic proceedings · 2011Article
- Cardiovascular events in statin recipients: impact of adherence to treatment in a 3-year record linkage study.European journal of clinical pharmacology · 2011Article
- Statins for children? A word of caution.European journal of clinical pharmacology · 2009Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the pattern of use of statins in the Emilia Romagna Region, with a focus on the therapeutic regimens and the patient's risk profile as predictors of adherence to therapy.
methodsAll patients from Emilia Romagna (4,027,275 inhabitants) receiving statin prescriptions in January-February 2005 were selected and observed for 12 months in terms of their statin regimen and use of other drugs for cardiovascular risk prevention. Previous hospital admissions for major cardiovascular events were also obtained. Adherence to statins was evaluated in terms of coverage (covered: >or=300 tablets/year). The relationship between coverage and risk profile (age, sex, other cardiovascular drugs, previous cardiovascular events and choice of drugs/dosages) was analysed by multivariate logistic regression.
resultsAmong the 137,217 patients receiving at least one prescription in the observation period, the rate of coverage was 46%. Coverage was statistically higher in patients with a previous hospital admission (secondary prevention) [Odds ratio (OR) 1.19; 95% confidence interval (95% CI) 1.16, 1.22], in those concomitantly treated with three to four different cardiovascular drugs (OR 2.77; 95% CI 2.66, 2.89). The coverage was also statistically higher in patients aged 50-69 years (OR 1.14; 95% CI 1.08, 1.20) and among males (OR 1.21; 95% CI 1.18, 1.23).
conclusionsLess than half of patients receiving statin therapy took their medication daily, with a coverage only slightly higher in patients at higher cardiovascular risk. Three-quarters of the patients received statin therapy in primary prevention, whereas the benefits of statins are documented mostly for patients in secondary prevention. These findings strengthen the need to sensitise physicians and patients to the correct use of statins.
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