ArticleJournal of lipid research2008
Increased thermoregulation in cold-exposed transgenic mice overexpressing lipoprotein lipase in skeletal muscle: an avian phenotype?
Article in Journal of lipid research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- The response to fasting and refeeding reveals functional regulation of lipoprotein lipase proteoforms.Frontiers in physiology · 2023Article
- Lipoprotein Lipase Is a Feature of Alternatively-Activated Microglia and May Facilitate Lipid Uptake in the CNS During Demyelination.Frontiers in molecular neuroscience · 2018Article
- Muscle Non-shivering Thermogenesis and Its Role in the Evolution of Endothermy.Frontiers in physiology · 2017Review
- Sarcolipin: A Key Thermogenic and Metabolic Regulator in Skeletal Muscle.Trends in endocrinology and metabolism: TEM · 2016Review
- Lipoprotein lipase is an important modulator of lipid uptake and storage in hypothalamic neurons.Biochemical and biophysical research communications · 2015Article
- Differential effects of angiopoietin-like 4 in brain and muscle on regulation of lipoprotein lipase activity.Molecular metabolism · 2015Article
- Mice lacking G0S2 are lean and cold-tolerant.Cancer biology & therapy · 2014Article
- Article
- Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity.Cell death & disease · 2012Article
- Exercise reduces appetite and traffics excess nutrients away from energetically efficient pathways of lipid deposition during the early stages of weight regain.American journal of physiology. Regulatory, integrative and comparative physiology · 2011Article
- Deficiency of lipoprotein lipase in neurons modifies the regulation of energy balance and leads to obesity.Cell metabolism · 2011Article
- Skin-specific deletion of stearoyl-CoA desaturase-1 alters skin lipid composition and protects mice from high fat diet-induced obesity.The Journal of biological chemistry · 2009Article
- The metabolic syndrome.Endocrine reviews · 2008Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
LPL is an enzyme involved in the breakdown and uptake of lipoprotein triglycerides. In the present study, we examined how the transgenic (Tg) overexpression of human LPL in mouse skeletal muscle affected tolerance to cold temperatures, cold-induced thermogenesis, and fuel utilization during this response. Tg mice and their nontransgenic controls were placed in an environmental chamber and housed in metabolic chambers that monitored oxygen consumption and carbon dioxide production with calorimetry. When exposed to 4 degrees C, an attenuation in the decline in body temperature in Tg mice was accompanied by an increased metabolic rate (15%; P < 0.001) and a reduction in respiratory quotient (P < 0.05). Activity levels, the expression of uncoupling proteins in brown fat and muscle, and lean mass failed to explain the enhanced cold tolerance and thermogenesis in Tg mice. The more oxidative type IIa fibers were favored over the more glycolytic type IIb fibers (P < 0.001) in the gastrocnemius and quadriceps muscles of Tg mice. These data suggest that Tg overexpression of LPL in skeletal muscle increases cold tolerance by enhancing the capacity for fat oxidation, producing an avian-like phenotype in which skeletal muscle contributes significantly to the thermogenic response to cold temperatures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.