Evidence map›Paper›PMID 18175209›Full record

ReviewJournal of bioenergetics and biomembranes2007

Transport ATPases into the year 2008: a brief overview related to types, structures, functions and roles in health and disease.

Peter L Pedersen

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of bioenergetics and biomembranes, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 109 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Acute Stress in Lesser-Spotted Catshark (Animals : an open access journal from MDPI · 2022
    Article
  6. Article
  7. Review
  8. Pump Proton and Laryngeal HInternational journal of general medicine · 2020
    Review
  9. Review
  10. Article
  11. Article
  12. ATP synthase β-subunit abnormality in pancreas islets of rats with polycystic ovary syndrome and type 2 diabetes mellitus.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017
    Article
  13. Article
  14. Cd(2+) extrusion by P-type Cd(2+)-ATPase of Staphylococcus aureus 17810R via energy-dependent Cd(2+)/H(+) exchange mechanism.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2016
    Article
  15. Review
  16. Molecular Analysis by Gene Expression of Mitochondrial ATPase Subunits in Papillary Thyroid Cancer: Is ATP5E Transcript a Possible Early Tumor Marker?Medical science monitor : international medical journal of experimental and clinical research · 2015
    Observational
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Peter L PedersenDepartment of Biological Chemistry, Johns Hopkins University, School of Medicine, 725 North Wolfe Street, Baltimore, MA 21205-2185, USA. ppederse@jhmi.edu
Johns Hopkins University · US

Funding

CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIAR01CA010951 · NCI · JOHNS HOPKINS UNIVERSITY · PI PEDERSEN, PETER L · 1985 to 2009
$3.7M
CONTROL OF ENZYMATIC PHOSPHATE TRANSFER IN MITOCHONDRIAR37CA010951 · NCI · JOHNS HOPKINS UNIVERSITY · PI PEDERSEN, PETER L · 1989 to 1998
–
NCI NIH HHS CA 10951NCI NIH HHS CA 80018
6 · The paper itself

Abstract

Transport ATPases can be lumped into four distinct types, P, F, V, and ABC, with the first three designated 20 years ago (Pedersen, P.L. and Carafoli, E., Trends Biochem. Sci. 12, 146-150, 1987) and the ABC type included more recently. The mini-reviews (>20) that comprise this volume of the Journal of Bioenergetics and Biomembranes describe work presented at the 2007 FASEB Conference (6th) on Transport ATPases (Kathleen Sweadner, Chair; Rajini Rao, Co-Chair). Since these conferences began in 1997, the "transport ATPase field" has seen tremendous progress. Advances include a much better understanding of the structure, mechanism, and regulation of each of the four major ATPase types as well as their physiological and medical relevance. In fact, the transport ATPase field has entered a new era in which work on these enzymes is likely to contribute to new therapies for multiple diseases that affect both people and animals. Among these are cancer and heart disease, mitochondrial diseases, osteoporosis, macromolecular degeneration, immune deficiency, cystic fibrosis, diabetes, ulcers, nephro-toxicity, hearing loss, skin disorders, lupus, and malaria. In addition, as several members of the transport ATPase family include those involved in drug resistance their study may help alleviate this recurring problem in drug development. Finally, the transport ATPase field is also paving the way for nanotechnology focused on nano-motors with work on the F-type ATPases (F(0)F(1)) leading the way. These ATPases driven in reverse by a proton gradient have the capacity to interconvert electrochemical energy into mechanical energy and finally into chemical energy conserved in the terminal bond of ATP. In mammalian mitochondria these events occur on a larger complex or "nano-machine" called the "ATP synthasome" that consists of the ATP synthase in complex formation with carriers for P(i) and ADP/ATP.

Indexed as

Adenosine TriphosphatasesCarrier ProteinsAnimalsATP-Binding Cassette TransportersDiseaseHumansIon TransportProton-Translocating ATPasesVacuolar Proton-Translocating ATPasesAdenosine TriphosphatasesATP-Binding Cassette TransportersCarrier ProteinsProton-Translocating ATPasesVacuolar Proton-Translocating ATPases

Identifiers

PMID18175209
OpenAlexW1989755438

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.