ArticleEnvironmental health perspectives2007
Endocrine-disrupting potential of bisphenol A, bisphenol A dimethacrylate, 4-n-nonylphenol, and 4-n-octylphenol in vitro: new data and a brief review.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
139 citing papers in PubMed, 2 syntheses or guidelines pooled it, 493 citations in OpenAlex.
- An updated systematic review on the possible effect of nonylphenol on male fertility.Environmental science and pollution research international · 2017Pooled it
- Bisphenol S and F: A Systematic Review and Comparison of the Hormonal Activity of Bisphenol A Substitutes.Environmental health perspectives · 2015Pooled it
- Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization.Fertility and sterility · 2011Trial
- A bio-based superhydrophobic pit and fissure sealant for enhanced stability and anticaries application.Materials today. Bio · 2026Article
- Review of in vitro approaches for assessing the toxicity of chemical stressors across diverse physiological systems.Toxicological sciences : an official journal of the Society of Toxicology · 2026Review
- Prevalent detection of multiclass environmental chemicals in paired CSF and plasma samples and their potential associations with postpartum depressive symptoms in pregnant women.Environmental research · 2026Article
- Use of Chemical Hair Straighteners and Menstrual Disturbances.Journal of women's health (2002) · 2026Article
- Protective effects of panax ginseng against bisphenol a-induced testicular toxicity in rats.International journal of impotence research · 2026Article
- Prenatal bisphenol A exposure perturbs sex-dependent transcriptomic regionalization of autism-associated genes in the developing brain.Biology direct · 2026Article
- The sequential use of IVF disposable devices doesn't cause cumulative toxicity unless a defective device compromises the entire procedure.Scientific reports · 2026Article
- Dental composite-resin materials and oral-systemic health: clinical toxicology insights.Frontiers in public health · 2026Review
- Disrupting Defenses: Effects of Bisphenol A and Its Analogs on Human Antibody Production In Vitro.Life (Basel, Switzerland) · 2025Article
- Association between Urinary Phenols and Parabens as Well as Breast Cancer.Iranian journal of public health · 2025Article
- Bisphenol-F and Bisphenol-S (BPF and BPS) Impair the Stemness of Neural Stem Cells and Neuronal Fate Decision in the Hippocampus Leading to Cognitive Dysfunctions.Molecular neurobiology · 2024Article
- Endocrine disruptors, aryl hydrocarbon receptor and cortisol secretion.Journal of endocrinological investigation · 2024Review
- Effects of microplastic interaction with persistent organic pollutants on the activity of the aryl hydrocarbon and estrogen receptors.Chemosphere · 2024Article
- Interaction of Bisphenol A and Its Analogs with Estrogen and Androgen Receptor from Atlantic Cod (Environmental science & technology · 2024Article
- Regrettable Substitutes and the Brain: What Animal Models and Human Studies Tell Us about the Neurodevelopmental Effects of Bisphenol, Per- and Polyfluoroalkyl Substances, and Phthalate Replacements.International journal of molecular sciences · 2024Review
- Article
- Prenatal bisphenol A and/or diethylhexyl phthalate exposure followed by adult estradiol treatment affects behavior and brain monoamines in female rat offspring.Frontiers in endocrinology · 2024Article
79 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAn array of environmental compounds is known to possess endocrine disruption (ED) potentials. Bisphenol A (BPA) and bisphenol A dimethacrylate (BPA-DM) are monomers used to a high extent in the plastic industry and as dental sealants. Alkylphenols such as 4-n-nonylphenol (nNP) and 4-n-octylphenol (nOP) are widely used as surfactants.
objectivesWe investigated the effect in vitro of these four compounds on four key cell mechanisms including transactivation of a) the human estrogen receptor (ER), b) the human androgen receptor (AR), c) the aryl hydrocarbon receptor (AhR), and d) aromatase activity.
resultsAll four compounds inhibited aromatase activity and were agonists and antagonists of ER and AR, respectively. nNP increased AhR activity concentration-dependently and further increased the 2,3,7,8-tetrachlorodibenzo-p-dioxin AhR action. nOP caused dual responses with a weak increased and a decreased AhR activity at lower (10(-8) M) and higher concentrations (10(-5)-10(-4) M), respectively. AhR activity was inhibited with BPA (10(-5)-10(-4) M) and weakly increased with BPA-DM (10(-5) M), respectively. nNP showed the highest relative potency (REP) compared with the respective controls in the ER, AhR, and aromatase assays, whereas similar REP was observed for the four chemicals in the AR assay.
conclusionOur in vitro data clearly indicate that the four industrial compounds have ED potentials and that the effects can be mediated via several cellular pathways, including the two sex steroid hormone receptors (ER and AR), aromatase activity converting testosterone to estrogen, and AhR; AhR is involved in syntheses of steroids and metabolism of steroids and xenobiotic compounds.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.