ArticleEnvironmental health perspectives2007
Xenoandrogenic activity in serum differs across European and Inuit populations.
Article in Environmental health perspectives, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 26 citations in OpenAlex.
- Time Trend of Persistent Organic Pollutants and Metals in Greenlandic Inuit during 1994-2015.International journal of environmental research and public health · 2021Article
- Endocrine-Mediated Mechanisms of Metabolic Disruption and New Approaches to Examine the Public Health Threat.Frontiers in endocrinology · 2019Review
- Parenteral exposure to pesticides and occurence of congenital malformations: hospital-based case-control study.BMC pediatrics · 2016Article
- Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo.Basic & clinical pharmacology & toxicology · 2014Review
- Association between environmental contaminants and health outcomes in indigenous populations of the Circumpolar North.International journal of circumpolar health · 2014Review
- Perfluorinated compounds are related to breast cancer risk in Greenlandic Inuit: a case control study.Environmental health : a global access science source · 2011Article
- Environmental/lifestyle effects on spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Xenohormone transactivities are inversely associated to serum POPs in Inuit.Environmental health : a global access science source · 2008Article
- Fertility and markers of male reproductive function in Inuit and European populations spanning large contrasts in blood levels of persistent organochlorines.Environmental health perspectives · 2008Review
- Semen quality in relation to xenohormone and dioxin-like serum activity among Inuits and three European populations.Environmental health perspectives · 2007Article
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Authors and funding
13 authors at 7 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnimal and in vitro studies have indicated that human male reproductive disorders can arise as a result of disrupted androgen receptor (AR) signalling by persistent organic pollutants (POPs). Our aim in the present study was to compare serum xenoandrogenic activity between study groups with different POP exposures and to evaluate correlations to the POP proxy markers 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE).
methodsWe determined xenoandrogenic activity in the serum fraction containing the lipophilic POPs but free of endogenous hormones. Adult male serum (n = 261) from Greenland, Sweden, Warsaw (Poland), and Kharkiv (Ukraine) was analyzed. Xenoandrogenic activity was determined as the effect of serum extract alone (XAR) and in the presence of the synthetic AR agonist R1881 (XARcomp) on AR transactivated luciferase activity.
resultsThe study groups differed significantly with respect to XARcomp activity, which was increased in the Inuits and decreased in the European study groups; we observed no difference for XAR activity. We found the highest level of the AR antagonist p,p'-DDE in Kharkiv, and accordingly, this study group showed the highest percent of serum samples with decreased XARcomp activities. Furthermore, the percentage of serum samples with decreased XARcomp activities followed the p,p'-DDE serum level for the European study groups. No correlations between serum XAR or XARcomp activities and the two POP markers were revealed.
conclusionsThe differences in XARcomp serum activity between the study groups suggest differences in chemical exposure profiles, genetics, and/or lifestyle factors.
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