ArticleNucleic acids research2008
SelenoDB 1.0 : a database of selenoprotein genes, proteins and SECIS elements.
Article in Nucleic acids research, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Overcoming the widespread flaws in the annotation of vertebrate selenoprotein genes in public databases.PLoS computational biology · 2026Article
- 3S-DB identifies an RNA repository facilitating stop codon readthrough for selenocysteine insertion and selenoproteome expansion.Redox biology · 2025Article
- Engineered mRNA-ribosome fusions for facile biosynthesis of selenoproteins.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Introduction to Bioinformatics Resources for Post-transcriptional Regulation of Gene Expression.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Bioinformatics of Selenoproteins.Antioxidants & redox signaling · 2020Review
- Role of Key Micronutrients from Nutrigenetic and Nutrigenomic Perspectives in Cancer Prevention.Medicina (Kaunas, Lithuania) · 2019Review
- Selenocysteine Insertion at a Predefined UAG Codon in a Release Factor 1 (RF1)-depletedThe Journal of biological chemistry · 2017Article
- Evolution of the Selenoproteome in Helicobacter pylori and Epsilonproteobacteria.Genome biology and evolution · 2015Article
- Review
- SelenoDB 2.0: annotation of selenoprotein genes in animals and their genetic diversity in humans.Nucleic acids research · 2014Article
- Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster.eLife · 2013Article
- A novel insight into the mechanism of mammalian selenoprotein synthesis.RNA (New York, N.Y.) · 2013Article
- Tuning the engine: an introduction to resources on post-transcriptional regulation of gene expression.RNA biology · 2012Review
- Computational identification of new structured cis-regulatory elements in the 3'-untranslated region of human protein coding genes.Nucleic acids research · 2012Article
- Encapsulated nanoepigallocatechin-3-gallate and elemental selenium nanoparticles as paradigms for nanochemoprevention.International journal of nanomedicine · 2012Review
- Nutrigenetics, nutrigenomics, and selenium.Frontiers in genetics · 2011Article
- The Micronutrient Genomics Project: a community-driven knowledge base for micronutrient research.Genes & nutrition · 2010Article
- Selenoprofiles: profile-based scanning of eukaryotic genome sequences for selenoprotein genes.Bioinformatics (Oxford, England) · 2010Article
- dbTEU: a protein database of trace element utilization.Bioinformatics (Oxford, England) · 2010Article
- Low exchangeability of selenocysteine, the 21st amino acid, in vertebrate proteins.Molecular biology and evolution · 2009Article
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Authors and funding
4 authors.
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Abstract
Selenoproteins are a diverse group of proteins usually misidentified and misannotated in sequence databases. The presence of an in-frame UGA (stop) codon in the coding sequence of selenoprotein genes precludes their identification and correct annotation. The in-frame UGA codons are recoded to cotranslationally incorporate selenocysteine, a rare selenium-containing amino acid. The development of ad hoc experimental and, more recently, computational approaches have allowed the efficient identification and characterization of the selenoproteomes of a growing number of species. Today, dozens of selenoprotein families have been described and more are being discovered in recently sequenced species, but the correct genomic annotation is not available for the majority of these genes. SelenoDB is a long-term project that aims to provide, through the collaborative effort of experimental and computational researchers, automatic and manually curated annotations of selenoprotein genes, proteins and SECIS elements. Version 1.0 of the database includes an initial set of eukaryotic genomic annotations, with special emphasis on the human selenoproteome, for immediate inspection by selenium researchers or incorporation into more general databases. SelenoDB is freely available at http://www.selenodb.org.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.