ArticleThe Journal of physiology2008
Biophysical properties of CaV1.3 calcium channels in gerbil inner hair cells.
Article in The Journal of physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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44 citing papers in PubMed, 78 citations in OpenAlex.
- Modeling developmental spiking behavior driven by ionic current dynamics of mouse and human inner hair cells using a calcium-enhanced Izhikevich framework.Journal of computational neuroscience · 2026Article
- Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis.Frontiers in cellular neuroscience · 2024Article
- Experimental animal models of drug-induced sensorineural hearing loss: a narrative review.Annals of translational medicine · 2021Review
- Synaptic Contributions to Cochlear Outer Hair Cell CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Encoding sound in the cochlea: from receptor potential to afferent discharge.The Journal of physiology · 2021Review
- Current Response in CaFrontiers in neuroscience · 2021Article
- RBP2 stabilizes slow Cav1.3 CaPflugers Archiv : European journal of physiology · 2020Article
- Hair Cell Afferent Synapses: Function and Dysfunction.Cold Spring Harbor perspectives in medicine · 2019Review
- How to Build a Fast and Highly Sensitive Sound Detector That Remains Robust to Temperature Shifts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Differential Gene Expression Patterns Between Apical and Basal Inner Hair Cells Revealed by RNA-Seq.Frontiers in molecular neuroscience · 2019Article
- Clustered CaCell reports · 2018Article
- Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry.Journal of neurophysiology · 2018Article
- Voltage-Gated Calcium Channels: Key Players in Sensory Coding in the Retina and the Inner Ear.Physiological reviews · 2018Review
- The Coupling between CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Membrane properties specialize mammalian inner hair cells for frequency or intensity encoding.eLife · 2015Article
- Calcium-Induced calcium release during action potential firing in developing inner hair cells.Biophysical journal · 2015Article
- EF-hand protein Ca2+ buffers regulate Ca2+ influx and exocytosis in sensory hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Elementary properties of Ca(2+) channels and their influence on multivesicular release and phase-locking at auditory hair cell ribbon synapses.Frontiers in cellular neuroscience · 2015Article
- Voltage-Gated Cav1 Channels in Disorders of Vision and Hearing.Current molecular pharmacology · 2015Review
- ATP hydrolysis is critically required for function of CaV1.3 channels in cochlear inner hair cells via fueling Ca2+ clearance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
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2 authors at 1 institution in 1 country.
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Abstract
The Ca(2+) current (I(Ca)) in prehearing and adult inner hair cells (IHCs), the primary sensory receptors of the mammalian cochlea, is mainly carried by L-type (Ca(V)1.3) Ca(2+) channels. I(Ca) in immature and adult IHCs triggers the release of neurotransmitter onto auditory afferent fibres in response to spontaneous action potentials (APs) or graded receptor potentials, respectively. We have investigated whether the biophysical properties of I(Ca) vary between low- and high-frequency IHCs during cochlear development and whether its inactivation influences cellular responses. I(Ca) was recorded from gerbil IHCs maintained near physiological recording conditions. The size of I(Ca) in adult IHCs was about a third of that in immature cells with no apparent difference along the cochlea at both stages. The activation kinetics of I(Ca) were significantly faster in high-frequency IHCs, with that of adult cells being more rapid than immature cells. The degree of I(Ca) inactivation was similar along the immature cochlea but larger in high- than low-frequency adult IHCs. This inactivation was greatly reduced with barium but not affected by changing the intracellular buffer (BAPTA instead of EGTA). Immature basal IHCs showed faster recovery of I(Ca) from inactivation than apical cells allowing them to support a higher AP frequency. I(Ca) in adult IHCs was more resistant to progressive inactivation following repeated voltage stimulation than that of immature cells. This suggests that adult IHCs are likely to be suited for sustaining rapid and repeated release of synaptic vesicles, which is essential for sound encoding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.