ArticleBMC surgery2008
Local radiotherapy of exposed murine small bowel: apoptosis and inflammation.
Article in BMC surgery, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- IL-17RA signaling promotes the dedifferentiation of Paneth progenitors through ADAM17 to regenerate gut epithelium post-irradiation.Nature communications · 2026Article
- Radioprotective potential of probiotics against gastrointestinal and neuronal toxicity: a preclinical study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Article
- RETRACTED: Inhibition of EphA2 by Dasatinib Suppresses Radiation-Induced Intestinal Injury.International journal of molecular sciences · 2020Article
- Patients with radiation enteritis present regulatory T cell impairment associated with CTLA-4.Immunologic research · 2020Article
- Osteoradionecrosis of the Chest Wall.Plastic and reconstructive surgery. Global open · 2020Article
- C/EBPδ protects from radiation-induced intestinal injury and sepsis by suppression of inflammatory and nitrosative stress.Scientific reports · 2019Article
- Pancreatic radiation effect in apoptosis-related rectal radiation toxicity.Journal of radiation research · 2018Article
- Abscopal effect of radiation on lymph node metastasis in esophageal carcinoma: A case report and literature review.Oncology letters · 2018Article
- An Integrated Multi-Omic Approach to Assess Radiation Injury on the Host-Microbiome Axis.Radiation research · 2016Article
- Article
- Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.Cancer letters · 2015Review
- Immunomodulatory effects of high-protein diet with resveratrol supplementation on radiation-induced acute-phase inflammation in rats.Journal of medicinal food · 2014Article
- Double-blinded, randomized, placebo-controlled study to evaluate the effectiveness of green tea in preventing acute gastrointestinal complications due to radiotherapy.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2014Article
- Inflammation and immunity in radiation damage to the gut mucosa.BioMed research international · 2013Review
- Article
- MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreoperative radiotherapy of the pelvic abdomen presents with complications mostly affecting the small bowel. The aim of this study was to define the features of early radiation-induced injury on small bowel.
methods54 mice were divided into two groups (36 irradiated and 18 sham irradiated). Animals were placed on a special frame and (in the radiated group) the exteriorized segment of ileum was subjected to a single absorbed dose of 19 or 38 Gy radiation using 6 MV high energy photons. Specimens were collected for histology, immunohistochemistry (IHC) and ELISA analysis after 2, 24 and 48 hours. Venous blood was collected for systemic leucocyte count in a Burker chamber.
resultsHistology demonstrated progressive infiltration of inflammatory cells with cryptitis and increased apoptosis. MIP-2 (macrophage inflammatory protein) concentration was significantly increased in irradiated animals up to 48 hours. No significant differences were observed in IL-10 (interleukin) and TNF-alpha (tumour necrosis factor) levels. IHC with CD45 showed a significant increase at 2 hours of infiltrating leucocytes and lymphocytes after irradiation followed by progressive decrease with time. Caspase-3 expression increased significantly in a dose dependent trend in both irradiated groups up to 48 hours.
conclusionAcute small bowel injury caused by local irradiation is characterised by increased apoptosis of crypt epithelial cells and by lymphocyte infiltration of the underlying tissue. The severity of histological changes tends to be dose dependent and may affect the course of tissue damage.
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