Evidence map›Paper›PMID 18173770›Full record

ArticleJournal of anatomy2008

Calretinin in the peripheral nervous system of the adult zebrafish.

M B Levanti, G Montalbano, R Laurà, E Ciriaco, T Cobo, O García-Suarez, A Germanà, J A Vega

Open access · greenAbstract read
In one paragraph

Article in Journal of anatomy, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 23 citations in OpenAlex.

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  5. Characterization and Localization ofAnimals : an open access journal from MDPI · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

M B LevantiDipartmento di Morfologia, Biochimica, Fisiologia e Produzione Animale, Sezione di Morfologia, Facoltà di Medicina Veterinaria, Università di Messina, Italy.
G Montalbano
R Laurà
E Ciriaco
T Cobo
O García-Suarez
A Germanà
J A Vega
Universidad de Oviedo · ESIstituto Zooprofilattico Sperimentale Della Sicilia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Calretinin is a calcium-binding protein found widely distributed in the central nervous system and chemosensory cells of the teleosts, but its presence in the peripheral nervous system of fishes is unknown. In this study we used Western blot analysis and immunohistochemistry to investigate the occurrence and distribution of calretinin in the cranial nerve ganglia, dorsal root ganglia, sympathetic ganglia, and enteric nervous system of the adult zebrafish. By Western blotting a unique and specific protein band with an estimated molecular weight of around 30 kDa was detected, and it was identified as calretinin. Immunohistochemistry revealed that calretinin is selectively present in the cytoplasm of the neurons and never in the satellite glial cells. In both sensory and sympathetic ganglia the density of neurons that were immunolabelled, their size and morphology, as well as the intensity of immunostaining developed within the cytoplasm, were heterogeneous. In the enteric nervous system calretinin immunoreactivity was detected in a subset of enteric neurons as well as in a nerve fibre plexus localized inside the muscular layers. The present results demonstrate that in addition to the central nervous system, calretinin is also present in the peripheral nervous system of zebrafish, and contribute to completing the map of the distribution of this protein in the nervous system of teleosts.

Indexed as

AnimalsBlotting, WesternCalbindin 2Enteric Nervous SystemGanglia, SpinalGanglia, SympatheticImmunohistochemistryNeuronsNeurons, AfferentPeripheral Nervous SystemS100 Calcium Binding Protein GZebrafishZebrafish Proteinscalb2b protein, zebrafishCalbindin 2S100 Calcium Binding Protein GZebrafish Proteins

Identifiers

PMID18173770
PMCPMC2423389
OpenAlexW1734883581

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.