Evidence map›Paper›PMID 18172852›Full record

ArticleHuman brain mapping2009

Cortical dysfunction in patients with Huntington's disease during working memory performance.

Robert C Wolf, Nenad Vasic, Carlos Schönfeldt-Lecuona, Daniel Ecker, Georg Bernhard Landwehrmeyer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human brain mapping, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Review
  6. Review
  7. Review
  8. Article
  9. Review
  10. Rapid acquisition of dynamic control over DLPFC using real-time fMRI feedback.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2018
    Article
  11. Article
  12. Huntington's disease: the coming of age.Journal of genetics · 2018
    Review
  13. Article
  14. Article
  15. Article
  16. Longitudinal task-negative network analyses in preclinical Huntington's disease.European archives of psychiatry and clinical neuroscience · 2014
    Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Robert C WolfDepartment of Psychiatry III, University of Ulm, Leimgrubenweg 12-14, 89075 Ulm, Germany. christian.wolf@uni-ulm.de
Nenad Vasic
Carlos Schönfeldt-Lecuona
Daniel Ecker
Georg Bernhard Landwehrmeyer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Previous functional neuroimaging studies on executive function suggested multiple functionally aberrant cortical regions in patients with Huntington's disease (HD). However, little is known about the neural mechanisms of working memory (WM) function in this patient population. The objective of this study was to investigate the functional neuroanatomy of WM in HD patients. We used event-related functional magnetic resonance imaging and a parametric verbal WM task to investigate cerebral function during WM performance in 16 healthy control subjects and 12 mild to moderate stage HD patients. We excluded incorrectly performed trials to control for potential accuracy-related activation confounds. Voxel-based morphometry (VBM) was used to control for confounding cortical and subcortical atrophy. We found that HD patients were slower and less accurate than healthy controls across all WM load levels. In addition, HD patients showed lower activation in the left dorso- and ventrolateral prefrontal cortex, the left inferior parietal cortex, the left putamen, and the right cerebellum at high WM load levels only. VBM revealed gray matter differences in the bilateral caudate nucleus and the thalamus, as well as in inferior parietal and right lateral prefrontal regions. However, volumetric abnormalities in the patient group did not affect the activation differences obtained during WM task performance. These findings demonstrate that WM-related functional abnormalities in HD patients involve distinct WM network nodes associated with cognitive control and subvocal rehearsal. Moreover, aberrant cortical function in HD patients may occur in brain regions, which are relatively well preserved in terms of brain atrophy.

Indexed as

AdultAtrophyBrain MappingCerebellumCerebral CortexCognition DisordersCorpus StriatumDisability EvaluationDisease ProgressionFemaleFunctional LateralityHumansHuntington DiseaseMagnetic Resonance ImagingMaleMemory Disorders

Identifiers

PMID18172852
PMCPMC6870646

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.