ArticleCellular and molecular neurobiology2008
Correlation of plasma dopamine beta-hydroxylase activity with polymorphisms in DBH gene: a study on Eastern Indian population.
Article in Cellular and molecular neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Addiction pharmacogenetics: a systematic review of the genetic variation of the dopaminergic system.Psychiatric genetics · 2015Pooled it
- Pharmacogenetic randomized trial for cocaine abuse: disulfiram and dopamine β-hydroxylase.Biological psychiatry · 2013Trial
- Associations Between Dopamine Beta-Hydroxylase Gene Polymorphisms and Restless Legs Syndrome: A Case-Control Study.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A review of pharmacogenetic studies of substance-related disorders.Drug and alcohol dependence · 2015Review
- The C-1021T polymorphism of dopamine β-hydroxylase is not associated with orthostatic hypotension in a Chinese population.Journal of human hypertension · 2015Article
- Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.Circulation research · 2014Article
- Molecular and genetic basis of depression.Journal of genetics · 2014Review
- Genotype-independent decrease in plasma dopamine beta-hydroxylase activity in Alzheimer's disease.Progress in neuro-psychopharmacology & biological psychiatry · 2013Article
- DBH gene as predictor of response in a cocaine vaccine clinical trial.Neuroscience letters · 2013Article
- Individual differences in cognition, affect, and performance: behavioral, neuroimaging, and molecular genetic approaches.NeuroImage · 2012Review
- Article
- The dopamine β-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project.BMC medical genetics · 2010Article
- Study on DBH genetic polymorphisms and plasma activity in attention deficit hyperactivity disorder patients from Eastern India.Cellular and molecular neurobiology · 2010Article
- Pharmacogenetic treatments for drug addiction: cocaine, amphetamine and methamphetamine.The American journal of drug and alcohol abuse · 2009Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plasma dopamine beta-hydroxylase activity (plDbetaH) is tightly regulated by the DBH gene and several genetic polymorphisms have been found to independently exert their influence. In the present investigation, association of four DBH polymorphisms, DBH-STR, rs1611115, rs1108580, and rs2519152 with plDbetaH was examined in blood samples from 100 unrelated individuals belonging to the state of West Bengal, Eastern India. Genotypes obtained after PCR amplification and restriction digestion were used for statistical analyses. plDbetaH was measured using a photometric assay and its correlation with the genetic polymorphisms was analyzed using analysis of variance and linear regression. Moderate linkage disequilibrium (LD) was observed between DBH-STR and rs1611115, while rs1108580 and rs2519152 were in strong LD. 'T' allele of rs1611115 showed strong negative correlation with plDbetaH, whereas DBH-STR, rs1108580 and rs2519152 had no major effect. Four haplotypes showed significant influence on plDbetaH. This is the first report on the effect of genetic polymorphisms on plDbetaH from the Indian sub-continent. rs1611115 was the only polymorphism that showed substantial control over plDbetaH. Other polymorphisms which did not show individual effects could possibly be part of larger haplotype blocks that carry the functional polymorphisms controlling plDbetaH.
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