ArticleEuropean journal of pediatrics2008
Disrupted cerebellar development in preterm infants is associated with impaired neurodevelopmental outcome.
Article in European journal of pediatrics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 123 citations in OpenAlex.
- The impact of premature birth and low birth weight on motor, visual, and cognitive skills and mental health in adolescence: a systematic review and meta-analysis.European child & adolescent psychiatry · 2026Pooled it
- Age-Adjusted Cerebellar Volumetry and Developmental Outcomes in Extremely Low Birth Weight Infants.bioRxiv : the preprint server for biology · 2026Article
- Early-Life Clinical Factors Shape Cerebellar Structure in Preterm-Born Children.Annals of the Child Neurology Society · 2026Article
- Small for Gestational Age and Motor Development in Children: A Narrative Review of Risk Factors, Brain Mechanisms, and Early Interventions.Developmental neuroscience · 2025Review
- Cerebellar haemorrhage and atrophy in infants born extremely preterm with intraventricular haemorrhage.Developmental medicine and child neurology · 2025Article
- Cerebellar hemorrhage in neonates: pattern analysis by ultrasonography and magnetic resonance imaging.Pediatric radiology · 2025Article
- A Simple MRI Score Predicts Pathological General Movements in Very Preterm Infants with Brain Injury-Retrospective Cohort Study.Children (Basel, Switzerland) · 2024Article
- Fibrinogen inhibits sonic hedgehog signaling and impairs neonatal cerebellar development after blood-brain barrier disruption.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The significance of cerebellar contributions in early-life through aging.Frontiers in computational neuroscience · 2024Article
- Prevalence, Clinical Features, Neuroimaging, and Genetic Findings in Children With Ataxic Cerebral Palsy in Europe.Neurology · 2023Article
- Early development of sleep and brain functional connectivity in term-born and preterm infants.Pediatric research · 2022Review
- A novel RIP1/RIP3 dual inhibitor promoted OPC survival and myelination in a rat neonatal white matter injury model with hOPC graft.Stem cell research & therapy · 2021Article
- Commentary - Cerebellar underdevelopment in the very preterm infant: Important and underestimated source of cognitive deficits.Journal of neonatal-perinatal medicine · 2021Article
- Cerebellum and Prematurity: A Complex Interplay Between Disruptive and Dysmaturational Events.Frontiers in systems neuroscience · 2021Review
- YAP1 is involved in replenishment of granule cell precursors following injury to the neonatal cerebellum.Developmental biology · 2019Article
- Cerebellar Functional Connectivity in Term- and Very Preterm-Born Infants.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Longitudinal growth and emotional and behavioral problems at age 7 in moderate and late preterms.PloS one · 2019Article
- Longitudinal Preterm Cerebellar Volume: Perinatal and Neurodevelopmental Outcome Associations.Cerebellum (London, England) · 2018Observational
- Neonatal brain injury causes cerebellar learning deficits and Purkinje cell dysfunction.Nature communications · 2018Article
- Damaging de novo mutations diminish motor skills in children on the autism spectrum.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The unfavorable impact of prematurity on the developing cerebellum was recently recognized, but the outcome after impaired cerebellar development as a prematurity-related complication is hitherto not adequately documented. Therefore we compared 31 preterm patients with disrupted cerebellar development to a control group of 31 gender and gestational age matched premature infants with normal cerebellar development. Supratentorial brain injuries during the neonatal period were comparable between the groups. At a minimum age of 24 months motor and mental development was assessed by standardized tests. Disrupted cerebellar development was associated with significantly poorer scores both in the subtests for neuromotor (p < 0.001) and mental development (p < 0.001), respectively. Mixed CP was diagnosed in 48% of affected patients, whereas none of the patients of the control group had mixed CP. Microcephaly and epilepsy were significantly related to disrupted cerebellar development. Preterm patients with disrupted cerebellar development exhibit poorer outcome results in all investigated variables. The role of the cerebellum in neurodevelopment after prematurity seems to be underestimated so far.
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