ArticleProceedings of the National Academy of Sciences of the United States of America2008
Origins of barriers and barrierless folding in BBL.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 97 citations in OpenAlex.
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- The change of conditions does not affect Ros87 downhill folding mechanism.Scientific reports · 2020Article
- Aggregation-primed molten globule conformers of the p53 core domain provide potential tools for studying p53C aggregation in cancer.The Journal of biological chemistry · 2018Article
- pH-Dependent cooperativity and existence of a dry molten globule in the folding of a miniprotein BBL.Physical chemistry chemical physics : PCCP · 2018Article
- Metanetwork Transmission Model for Predicting a Malaria-Control Strategy.Frontiers in genetics · 2018Article
- Folding of apomyoglobin: Analysis of transient intermediate structure during refolding using quick hydrogen deuterium exchange and NMR.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- How cooperative are protein folding and unfolding transitions?Protein science : a publication of the Protein Society · 2016Review
- When fast is better: protein folding fundamentals and mechanisms from ultrafast approaches.The Biochemical journal · 2016Review
- Impacts of the charged residues mutation S48E/N62H on the thermostability and unfolding behavior of cold shock protein: insights from molecular dynamics simulation with Gō model.Journal of molecular modeling · 2016Article
- Fast-folding proteins under stress.Cellular and molecular life sciences : CMLS · 2015Review
- Fast protein folding kinetics.Quarterly reviews of biophysics · 2014Review
- Dodine as a protein denaturant: the best of two worlds?The journal of physical chemistry. B · 2013Article
- Mapping polymerization and allostery of hemoglobin S using point mutations.The journal of physical chemistry. B · 2013Article
- Quantification of Drive-Response Relationships Between Residues During Protein Folding.Journal of chemical theory and computation · 2013Article
- Using VIPT-jump to distinguish between different folding mechanisms: application to BBL and a Trpzip.Journal of the American Chemical Society · 2013Article
- Article
- αC helix as a switch in the conformational transition of Src/CDK-like kinase domains.The journal of physical chemistry. B · 2012Article
- Folding without charges.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Single-molecule observation of helix staggering, sliding, and coiled coil misfolding.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
In contrast to classical chemical phenomenology, theory suggests that proteins may undergo downhill folding without an activation barrier under certain thermodynamic conditions. Recently, the BBL protein was proposed to fold by such a downhill scenario, but discrepancies between experimental results found in different groups argue against this. After briefly reviewing the major experimental studies of the BBL folding mechanism, we show that simulations of both coarse-grained and atomistic models can reconcile the seemingly conflicting observations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.