ArticleGenes & development2008
Transcription factories are nuclear subcompartments that remain in the absence of transcription.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers.
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Who cites it
120 citing papers in PubMed.
- A functional overlap between actively transcribed genes and chromatin insulator elements.The EMBO journal · 2026Article
- Cell-type-specific loops linked to RNA polymerase II elongation in human neural differentiation.Cell genomics · 2024Article
- Cell type-specific loops linked to RNA polymerase II elongation in human neural differentiation.bioRxiv : the preprint server for biology · 2023Article
- Transcription modulates chromatin dynamics and locus configuration sampling.Nature structural & molecular biology · 2023Article
- RNA Pol II enters the ring of cohesin-mediated loop extrusion.Nature genetics · 2023Article
- RNA polymerase II dynamics shape enhancer-promoter interactions.Nature genetics · 2023Article
- Chromatin expansion microscopy reveals nanoscale organization of transcription and chromatin.Science (New York, N.Y.) · 2023Article
- Enhancer-promoter contact formation requires RNAPII and antagonizes loop extrusion.Nature genetics · 2023Article
- Spatially coherent diffusion of human RNA Pol II depends on transcriptional state rather than chromatin motion.Nucleus (Austin, Tex.) · 2022Article
- Transcriptional regulation and chromatin architecture maintenance are decoupled functions at theGenes & development · 2022Article
- Merging Established Mechanisms with New Insights: Condensates, Hubs, and the Regulation of RNA Polymerase II Transcription.Journal of molecular biology · 2022Review
- Application of the 3C Method to Study the Developmental Genes inFrontiers in genetics · 2022Article
- Chromatin Hubs: A biological and computational outlook.Computational and structural biotechnology journal · 2022Review
- Suppression of liquid-liquid phase separation by 1,6-hexanediol partially compromises the 3D genome organization in living cells.Nucleic acids research · 2021Article
- Delta.AR: An augmented reality-based visualization platform for 3D genome.Innovation (Cambridge (Mass.)) · 2021Article
- Principles of 3D compartmentalization of the human genome.Cell reports · 2021Article
- Direct DNA crosslinking with CAP-C uncovers transcription-dependent chromatin organization at high resolution.Nature biotechnology · 2021Article
- RNA Biogenesis Instructs Functional Inter-Chromosomal Genome Architecture.Frontiers in genetics · 2021Article
- Navigating the crowd: visualizing coordination between genome dynamics, structure, and transcription.Genome biology · 2020Review
- Review
60 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors.
Funding
Abstract
Nascent transcription occurs at nuclear foci of concentrated, hyperphosphorylated RNA polymerase II (RNAPII). We investigate RNAPII localization, distal gene co-association, and Hbb locus conformation during inhibition of transcription. Our results show distal active genes remain associated with RNAPII foci and each other in the absence of elongation. When initiation is inhibited, active genes dissociate from RNAPII foci and each other, suggesting initiation is necessary to tether distal active genes to shared foci. In the absence of transcription RNAPII foci remain, indicating they are not simple accumulations of RNAPII on transcribed genes but exist as independent nuclear subcompartments.
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