ArticleGenes & development2008
MicroRNAs in the Drosophila bithorax complex.
Article in Genes & development, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed.
- Female genetic variation controlling timing of mating plug ejection inbioRxiv : the preprint server for biology · 2026Article
- Upstream open reading frames repress the translation from the iab-8 RNA.PLoS genetics · 2024Article
- Regulation of alternative splicing and polyadenylation in neurons.Life science alliance · 2023Review
- A Compilation of the Diverse miRNA Functions inInternational journal of molecular sciences · 2023Review
- Recent Advances and Future Potential of Long Non-Coding RNAs in Insects.International journal of molecular sciences · 2023Review
- Pleiotropic fitness effects of the lncRNA Uhg4 in Drosophila melanogaster.BMC genomics · 2022Article
- Genomic and functional conservation of lncRNAs: lessons from flies.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- Repression of the Hox gene abd-A by ELAV-mediated Transcriptional Interference.PLoS genetics · 2021Article
- Article
- Identification of a micropeptide and multiple secondary cell genes that modulateProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Roles ofFrontiers in cell and developmental biology · 2021Review
- miRNAs and Neural Alternative Polyadenylation Specify the Virgin Behavioral State.Developmental cell · 2020Article
- Control of mating plug expelling and sperm storage in Drosophila: A gynandromorph- and mutation-based dissection.Biologia futura · 2019Article
- A Single MicroRNA-Hox Gene Module Controls Equivalent Movements in Biomechanically Distinct Forms of Drosophila.Current biology : CB · 2019Article
- The Role of miRNAs inGenetics · 2019Article
- MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in aDevelopment (Cambridge, England) · 2018Article
- Predicting microRNA targeting efficacy in Drosophila.Genome biology · 2018Article
- The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.PLoS genetics · 2018Article
- Metazoan MicroRNAs.Cell · 2018Review
- Pervasive Behavioral Effects of MicroRNA Regulation inGenetics · 2017Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The iab-4 noncoding RNA from the Drosophila bithorax complex is the substrate for a microRNA (miRNA). Gene conversion was used to delete the hairpin precursor of this miRNA; flies homozygous for this deletion are sterile. Surprisingly, this mutation complements with rearrangement breakpoint mutations that disrupt the iab-4 RNA but fails to complement with breaks mapping in the iab-5 through iab-7 regulatory regions. These breaks disrupt the iab-8 RNA, transcribed from the opposite strand. This iab-8 RNA also encodes a miRNA, detected on Northern blots, derived from the hairpin complementary to the iab-4 precursor hairpin. Ultrabithorax is a target of both miRNAs, although its repression is subtle in both cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.