ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2008
Vasopressin increases locomotion through a V1a receptor in orexin/hypocretin neurons: implications for water homeostasis.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 69 citations in OpenAlex.
- Hypothalamic control of arousal.Reviews in endocrine & metabolic disorders · 2026Review
- SARS-CoV-2 infection is associated with hypothalamic orexin suppression and persistent cortical NeuN attenuation.Journal of neuroinflammation · 2026Article
- A narrative review on oxytocin at the intersection of sleep, stress, and social behavior.Frontiers in neuroscience · 2026Review
- Divergent Learning-Related Transcriptional States of Cortical Glutamatergic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Does EGFR Signaling Mediate Orexin System Activity in Sleep Initiation?International journal of molecular sciences · 2023Review
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- Kisspeptin-8 Induces Anxiety-Like Behavior and Hypolocomotion by Activating the HPA Axis and Increasing GABA Release in the Nucleus Accumbens in Rats.Biomedicines · 2021Article
- Elucidation of Neural Circuits Involved in the Regulation of Sleep/Wakefulness Using Optogenetics.Advances in experimental medicine and biology · 2021Article
- Oxytocin and Vasopressin Systems in Obesity and Metabolic Health: Mechanisms and Perspectives.Current obesity reports · 2019Review
- Sex dependent impact of gestational stress on predisposition to eating disorders and metabolic disease.Molecular metabolism · 2018Article
- Monoamines Inhibit GABAergic Neurons in Ventrolateral Preoptic Area That Make Direct Synaptic Connections to Hypothalamic Arousal Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Non-Rapid Eye Movement Sleep Parasomnias and Migraine: A Role of Orexinergic Projections.Frontiers in neurology · 2018Article
- Orexin System: The Key for a Healthy Life.Frontiers in physiology · 2017Review
- Conditional ablation of orexin/hypocretin neurons: a new mouse model for the study of narcolepsy and orexin system function.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- AVP neurons in the paraventricular nucleus of the hypothalamus regulate feeding.Molecular metabolism · 2014Article
- Voluntary locomotion linked with cerebral activation is mediated by vasopressin V1a receptors in free-moving mice.The Journal of physiology · 2013Article
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- Role of orexin in modulating arousal, feeding, and motivation.Frontiers in behavioral neuroscience · 2013Article
- The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions.Frontiers in endocrinology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Water homeostasis is a critical challenge to survival for land mammals. Mice display increased locomotor activity when dehydrated, a behavior that improves the likelihood of locating new sources of water and simultaneously places additional demands on compromised hydration levels. The neurophysiology underlying this well known behavior has not been previously elucidated. We report that the anti-diuretic hormone arginine-vasopressin (AVP) is involved in this response. AVP and oxytocin directly induced depolarization and an inward current in orexin/hypocretin neurons. AVP-induced activation of orexin neurons was inhibited by a V1a receptor (V1aR)-selective antagonist and was not observed in V1aR knock-out mice, suggesting an involvement of V1aR. Subsequently activation of phospholipase Cbeta triggers an increase in intracellular calcium by both calcium influx through nonselective cation channels and calcium release from calcium stores in orexin neurons. Intracerebroventricular injection of AVP or water deprivation increased locomotor activity in wild-type mice, but not in transgenic mice lacking orexin neurons. V1aR knock-out mice were less active than wild-type mice. These results suggest that the activation of orexin neurons by AVP or oxytocin has an important role in the regulation of spontaneous locomotor activity in mice. This system appears to play a key role in water deprivation-induced hyperlocomotor activity, a response to dehydration that increases the chance of locating water in nature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.