ArticleJournal of structural biology2008
Structures of open (R) and close (T) states of prephenate dehydratase (PDT)--implication of allosteric regulation by L-phenylalanine.
Article in Journal of structural biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Article
- Soybean AROGENATE DEHYDRATASES (GmADTs): involvement in the cytosolic isoflavonoid metabolon or trans-organelle continuity?Frontiers in plant science · 2024Article
- Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants.Plant physiology · 2022Article
- The Komagataeibacter europaeus GqqA is the prototype of a novel bifunctional N-Acyl-homoserine lactone acylase with prephenate dehydratase activity.Scientific reports · 2021Article
- Structural and biochemical analysis of Bacillus anthracis prephenate dehydrogenase reveals an unusual mode of inhibition by tyrosine via the ACT domain.The FEBS journal · 2020Article
- Uncoupling conformational states from activity in an allosteric enzyme.Nature communications · 2017Article
- X-ray Scattering Studies of Protein Structural Dynamics.Chemical reviews · 2017Review
- Subcellular localization of Arabidopsis arogenate dehydratases suggests novel and non-enzymatic roles.Journal of experimental botany · 2017Article
- Characterization of two key enzymes for aromatic amino acid biosynthesis in symbiotic archaea.Extremophiles : life under extreme conditions · 2016Article
- Domain Movements upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-ray Scattering.Journal of the American Chemical Society · 2016Article
- Identification of the Allosteric Site for Phenylalanine in Rat Phenylalanine Hydroxylase.The Journal of biological chemistry · 2016Article
- Article
- Structural mechanism for the arginine sensing and regulation of CASTOR1 in the mTORC1 signaling pathway.Cell discovery · 2016Article
- Phylobiochemical characterization of class-Ib aspartate/prephenate aminotransferases reveals evolution of the plant arogenate phenylalanine pathway.The Plant cell · 2014Article
- X-ray structure of prephenate dehydratase from Streptococcus mutans.Journal of microbiology (Seoul, Korea) · 2014Article
- Contribution of the nos-pdt operon to virulence phenotypes in methicillin-sensitive Staphylococcus aureus.PloS one · 2014Article
- Article
- The crystal structures of the α-subunit of the α(2)β (2) tetrameric Glycyl-tRNA synthetase.Journal of structural and functional genomics · 2012Article
- 13C isotope effect on the reaction catalyzed by prephenate dehydratase.Biochimica et biophysica acta · 2010Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The enzyme prephenate dehydratase (PDT) converts prephenate to phenylpyruvate in L-phenylalanine biosynthesis. PDT is allosterically regulated by L-Phe and other amino acids. We report the first crystal structures of PDT from Staphylococcus aureus in a relaxed (R) state and PDT from Chlorobium tepidum in a tense (T) state. The two enzymes show low sequence identity (27.3%) but the same prototypic architecture and domain organization. Both enzymes are tetramers (dimer of dimers) in crystal and solution while a PDT dimer can be regarded as a basic catalytic unit. The N-terminal PDT domain consists of two similar subdomains with a cleft in between, which hosts the highly conserved active site. In one PDT dimer two clefts are aligned to form an extended active site across the dimer interface. Similarly at the interface two ACT regulatory domains create two highly conserved pockets. Upon binding of the L-Phe inside the pockets, PDT transits from an open to a closed conformation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.