ArticleBMC plant biology2008
Bioinformatic analysis of the CLE signaling peptide family.
Article in BMC plant biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 96 papers.
What it found
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Who cites it
96 citing papers in PubMed, 421 citations in OpenAlex.
- Evolutionary shifts in plant adaptation mediated by phytohormones.Plant communications · 2026Review
- Genome-Wide Identification and Expression Analysis of theCurrent issues in molecular biology · 2026Article
- A plant CLE peptide and its fungal mimic promote arbuscular mycorrhizal symbiosis via CRN-mediated ROS suppression.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Genome-Wide Identification and Functional Analysis ofInternational journal of molecular sciences · 2025Article
- Peptide hormones in plants.Molecular horticulture · 2025Review
- The rise of CLAVATA: evidence for CLAVATA3 and WOX signaling in the fern gametophyte.The Plant journal : for cell and molecular biology · 2025Article
- Genome-wide identification ofFrontiers in plant science · 2025Article
- UncoveringInternational journal of molecular sciences · 2024Article
- Article
- Root-knot nematode modulates plant CLE3-CLV1 signaling as a long-distance signal for successful infection.Science advances · 2023Article
- Molecular Mechanisms of Regulation of Root Development by Plant Peptides.Plants (Basel, Switzerland) · 2023Review
- The CLAVATA3/ESR-related peptide family in the biofuel crop pennycress.Frontiers in plant science · 2023Article
- Small secreted peptides encoded on the wheat (Frontiers in plant science · 2022Article
- Evolution of RGF/GLV/CLEL Peptide Hormones and Their Roles in Land Plant Growth and Regulation.International journal of molecular sciences · 2021Article
- At the Root of Nodule Organogenesis: Conserved Regulatory Pathways Recruited by Rhizobia.Plants (Basel, Switzerland) · 2021Review
- Possible role of small secreted peptides (SSPs) in immune signaling in bryophytes.Plant molecular biology · 2021Article
- Genome-wide identification of CLE gene family and their potential roles in bolting and fruit bearing in cucumber (Cucumis sativus L.).BMC plant biology · 2021Article
- Functional analysis of the cotton CLE polypeptide signaling gene family in plant growth and development.Scientific reports · 2021Article
- Application of Synthetic Peptide CEP1 Increases Nutrient Uptake Rates Along Plant Roots.Frontiers in plant science · 2021Article
- Molecular Traits and Functional Analysis of the CLAVATA3/Endosperm Surrounding Region-Related Small Signaling Peptides in Three Species ofFrontiers in plant science · 2021Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPlants encode a large number of leucine-rich repeat receptor-like kinases. Legumes encode several LRR-RLK linked to the process of root nodule formation, the ligands of which are unknown. To identify ligands for these receptors, we used a combination of profile hidden Markov models and position-specific iterative BLAST, allowing us to detect new members of the CLV3/ESR (CLE) protein family from publicly available sequence databases.
resultsWe identified 114 new members of the CLE protein family from various plant species, as well as five protein sequences containing multiple CLE domains. We were able to cluster the CLE domain proteins into 13 distinct groups based on their pairwise similarities in the primary CLE motif. In addition, we identified secondary motifs that coincide with our sequence clusters. The groupings based on the CLE motifs correlate with known biological functions of CLE signaling peptides and are analogous to groupings based on phylogenetic analysis and ectopic overexpression studies. We tested the biological function of two of the predicted CLE signaling peptides in the legume Medicago truncatula. These peptides inhibit the activity of the root apical and lateral root meristems in a manner consistent with our functional predictions based on other CLE signaling peptides clustering in the same groups.
conclusionOur analysis provides an identification and classification of a large number of novel potential CLE signaling peptides. The additional motifs we found could lead to future discovery of recognition sites for processing peptidases as well as predictions for receptor binding specificity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.