ArticleBMC genomics2008
Genome-wide analysis of the interaction between the endosymbiotic bacterium Wolbachia and its Drosophila host.
Article in BMC genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
75 citing papers in PubMed.
- Comparative tissue-specific microbiome analyses identify keystone endosymbionts shaping pathogen interactions in dromedary camel ticks.BMC microbiology · 2026Article
- Article
- Differential gene expression in Chorthippus parallelus (Zetterstedt, 1821) (Orthoptera: Acrididae: Gomphocerinae) induced by Wolbachia infection.Insect science · 2025Article
- Generation of Monoclonal Cultures from Wolbachia-infected Drosophila melanogaster JW18 Cell Line.Journal of visualized experiments : JoVE · 2025Article
- The infectivity of virus particles from Wolbachia-infected Drosophila.BMC microbiology · 2025Article
- Understanding the role of trehalose in interactions betweenFrontiers in cellular and infection microbiology · 2025Review
- UnveilingFrontiers in cellular and infection microbiology · 2025Article
- A comprehensive review ofFrontiers in immunology · 2024Review
- Ovarian transcriptional response to Wolbachia infection in D. melanogaster in the context of between-genotype variation in gene expression.G3 (Bethesda, Md.) · 2023Article
- Single-cell transcriptome sequencing revealsProceedings. Biological sciences · 2023Article
- Detection and Assessment of Wolbachia pipientis Infection.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Analysis of Aedes aegypti microRNAs in response to Wolbachia wAlbB infection and their potential role in mosquito longevity.Scientific reports · 2022Article
- Transcriptional response ofThe Journal of general virology · 2022Article
- Male Age andmBio · 2021Article
- Association of Wolbachia with Gene Expression in Drosophila Testes.Microbial ecology · 2021Article
- Article
- Review
- A Role for Maternal Factors in Suppressing Cytoplasmic Incompatibility.Frontiers in microbiology · 2020Article
- Molecular detection and identification of Wolbachia endosymbiont in fleas (Insecta: Siphonaptera).Folia microbiologica · 2019Article
- How do Wolbachia modify the Drosophila ovary? New evidences support the "titration-restitution" model for the mechanisms of Wolbachia-induced CI.BMC genomics · 2019Article
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundIntracellular Wolbachia bacteria are obligate, maternally-inherited, endosymbionts found frequently in insects and other invertebrates. The success of Wolbachia can be attributed in part to an ability to alter host reproduction via mechanisms including cytoplasmic incompatibility (CI), parthenogenesis, feminization and male killing. Despite substantial scientific effort, the molecular mechanisms underlying the Wolbachia/host interaction are unknown.
resultsHere, an in vitro Wolbachia infection was generated in the Drosophila S2 cell line, and transcription profiles of infected and uninfected cells were compared by microarray. Differentially-expressed patterns related to reproduction, immune response and heat stress response are observed, including multiple genes that have been previously reported to be involved in the Wolbachia/host interaction. Subsequent in vivo characterization of differentially-expressed products in gonads demonstrates that Angiotensin Converting Enzyme (Ance) varies between Wolbachia infected and uninfected flies and that the variation occurs in a sex-specific manner. Consistent with expectations for the conserved CI mechanism, the observed Ance expression pattern is repeatable in different Drosophila species and with different Wolbachia types. To examine Ance involvement in the CI phenotype, compatible and incompatible crosses of Ance mutant flies were conducted. Significant differences are observed in the egg hatch rate resulting from incompatible crosses, providing support for additional experiments examining for an interaction of Ance with the CI mechanism.
conclusionWolbachia infection is shown to affect the expression of multiple host genes, including Ance. Evidence for potential Ance involvement in the CI mechanism is described, including the prior report of Ance in spermatid differentiation, Wolbachia-induced sex-specific effects on Ance expression and an Ance mutation effect on CI levels. The results support the use of Wolbachia infected cell cultures as an appropriate model for predicting in vivo host/Wolbachia interactions.
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