ArticlePsychopharmacology2008
Effect of quinolinic acid-induced lesions of the nucleus accumbens core on performance on a progressive ratio schedule of reinforcement: implications for inter-temporal choice.
Article in Psychopharmacology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Striatal dopamine D2 receptors regulate effort but not value-based decision making and alter the dopaminergic encoding of cost.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Nucleus accumbens core lesions induce sub-optimal choice and reduce sensitivity to magnitude and delay in impulsive choice tasks.Behavioural brain research · 2018Article
- Neural substrates underlying effort, time, and risk-based decision making in motivated behavior.Neurobiology of learning and memory · 2016Review
- Quantitative analysis of performance on a progressive-ratio schedule: effects of reinforcer type, food deprivation and acute treatment with Δ⁹-tetrahydrocannabinol (THC).Behavioural processes · 2015Article
- Evidence for a role of 5-HT2C receptors in the motor aspects of performance, but not the efficacy of food reinforcers, in a progressive ratio schedule.Psychopharmacology · 2015Article
- Mechanisms of Individual Differences in Impulsive and Risky Choice in Rats.Comparative cognition & behavior reviews · 2015Article
- Effect of streptozotocin-induced diabetes on performance on a progressive ratio schedule.Psychopharmacology · 2014Article
- Interactions of timing and prediction error learning.Behavioural processes · 2014Review
- Article
- A quantitative analysis of the effects of qualitatively different reinforcers on fixed ratio responding in inbred strains of mice.Neurobiology of learning and memory · 2013Article
- A theory of behaviour on progressive ratio schedules, with applications in behavioural pharmacology.Psychopharmacology · 2012Review
- Motivation and timing: clues for modeling the reward system.Behavioural processes · 2012Review
- Nucleus accumbens neurons encode predicted and ongoing reward costs in rats.The European journal of neuroscience · 2011Article
- External incentives and internal states guide goal-directed behavior via the differential recruitment of the nucleus accumbens and the medial prefrontal cortex.Neuroscience · 2010Article
- Quantitative analysis of the effect of lesions of the subthalamic nucleus on intertemporal choice: further evidence for enhancement of the incentive value of food reinforcers.Behavioural pharmacology · 2009Article
- Effect of reinforcer magnitude on performance maintained by progressive-ratio schedules.Journal of the experimental analysis of behavior · 2009Article
- Effect of quinolinic acid-induced lesions of the subthalamic nucleus on performance on a progressive-ratio schedule of reinforcement: a quantitative analysis.Behavioural brain research · 2008Article
- Effect of disconnecting the orbital prefrontal cortex from the nucleus accumbens core on inter-temporal choice behaviour: a quantitative analysis.Behavioural brain research · 2008Article
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8 authors.
Funding
Abstract
rationaleThe nucleus accumbens core (AcbC) is believed to contribute to the control of operant behaviour by reinforcers. Recent evidence suggests that it is not crucial for determining the incentive value of immediately available reinforcers, but is important for maintaining the values of delayed reinforcers.
objectiveThis study aims to examine the effect of AcbC lesions on performance on a progressive-ratio schedule using a quantitative model that dissociates effects of interventions on motor and motivational processes (Killeen 1994 Mathematical principles of reinforcement. Behav Brain Sci 17:105-172). MATERIALS AND
methodsRats with bilateral quinolinic acid-induced lesions of the AcbC (n = 15) or sham lesions (n = 14) were trained to lever-press for food-pellet reinforcers under a progressive-ratio schedule. In Phase 1 (90 sessions) the reinforcer was one pellet; in Phase 2 (30 sessions), it was two pellets; in Phase 3, (30 sessions) it was one pellet.
resultsThe performance of both groups conformed to the model of progressive-ratio performance (group mean data: r2 > 0.92). The motor parameter, delta, was significantly higher in the AcbC-lesioned than the sham-lesioned group, reflecting lower overall response rates in the lesioned group. The motivational parameter, a, was sensitive to changes in reinforcer size, but did not differ significantly between the two groups. The AcbC-lesioned group showed longer post-reinforcement pauses and lower running response rates than the sham-lesioned group.
conclusionsThe results suggest that destruction of the AcbC impairs response capacity but does not alter the efficacy of food reinforcers. The results are consistent with recent findings that AcbC lesions do not alter sensitivity to reinforcer size in inter-temporal choice schedules.
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