ArticleTheScientificWorldJournal2007
Changes in allergy symptoms and depression scores are positively correlated in patients with recurrent mood disorders exposed to seasonal peaks in aeroallergens.
Article in TheScientificWorldJournal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00770068 (Seasonality of Depression and Airborne Allergens), which is not on this map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Seasonality of Depression and Airborne Allergens
Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- Psychological stress and its relationship with persistent allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2016Trial
- Pollen effects in a changing climate: Ragweed pollen exposure and sleepiness in immunotherapy patients of a Southeastern Michigan allergy clinic.International journal of biometeorology · 2024Article
- Factor Structures in the Depressive Symptoms Domains in the 9Q for Northern Thai Adults and Their Association with Chronic Diseases.Behavioral sciences (Basel, Switzerland) · 2024Article
- Analysis of Quality of Life and Mental Health in Patients With Atopic Dermatitis, Asthma and Allergic Rhinitis Using a Nation-wide Database, KNHANES VII.Allergy, asthma & immunology research · 2022Article
- Higher rates of allergies, autoimmune diseases and low-grade inflammation markers in treatment-resistant major depression.Brain, behavior, & immunity - health · 2021Article
- Clinical characteristics and sociodemographic features of psychotic major depression.Annals of general psychiatry · 2021Article
- A glimpse into the psychological status of E.N.T inpatients in China: A cross-sectional survey of three hospitals in different regions.World journal of otorhinolaryngology - head and neck surgery · 2019Article
- Mood Worsening on Days with High Pollen Counts is associated with a Summer Pattern of Seasonality.Pteridines · 2019Article
- Seasonal Allergies and Psychiatric Disorders in the United States.International journal of environmental research and public health · 2018Article
- Mental Health in Allergic Rhinitis: Depression and Suicidal Behavior.Current treatment options in allergy · 2017Article
- Seasonal variation of depressive symptoms in unipolar major depressive disorder.Comprehensive psychiatry · 2014Article
- A pilot genome wide association and gene expression array study of suicide with and without major depression.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2013Article
- Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents.Brain, behavior, and immunity · 2009Article
- Allergy: a risk factor for suicide?Current treatment options in neurology · 2008Article
- Changes in Severity of Allergy and Anxiety Symptoms Are Positively Correlated in Patients with Recurrent Mood Disorders Who Are Exposed to Seasonal Peaks of Aeroallergens.International journal of child health and human development : IJCHD · 2008Article
- Asthma and Mood Disorders.International journal of child health and human development : IJCHD · 2008Article
- Allergen Specific IgE, Number and Timing of Past Suicide Attempts, and Instability in Patients with Recurrent Mood Disorders.International journal of child health and human development : IJCHD · 2008Article
- The impact of work environment on mood disorders and suicide: Evidence and implications.International journal on disability and human development : IJDHD · 2008Article
- Evaluation of the safety of conventional lighting replacement by artificial daylight.Journal of microscopy and ultrastructureArticle
- Sickness Behavior and Seasonal Affective Disorder: An Immunological Perspective of Depression.Indian journal of psychological medicineArticle
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Funding
Abstract
Although growing evidence supports an association between allergy, allergens and depression, it remains unknown if this relationship is between "states" (possible triggers) or "traits" (possible vulnerabilities). We hypothesized that patients with recurrent mood disorders who are sensitized to tree pollen (as determined by allergen specific IgE antibodies), in comparison to those who are not sensitized, would report larger negative changes in mood during exposure to tree pollen in spring. We also hypothesized that differences between high and low tree pollen periods in self reported allergy symptoms would correlate positively with differences in self reported depression scores. We present 1-year preliminary data on the first 51 patients with unipolar or bipolar disorder (age: 19-63 years, 65% female, twelve patients were tree-pollen IgE positive). Ratings of mood and allergic disease status were performed once during the peak airborne pollen counts and once during the period of low airborne pollen counts, as reported by two local pollen counting stations. Linear regression models were developed to examine associations of changes in depression scores (dependent variable) with tree pollen sensitization, changes in the allergy symptom severity score, adjusted for gender and order of testing. We did not confirm the hypothesized relationship between a specific tree pollen sensitization and changes in mood during tree pollen exposure. We did confirm the hypothesized positive relationship between the changes in allergy symptoms and changes in subjects' depression scores (adjusted p<0.05). This result is consistent with previous epidemiological evidence connecting allergy with depression, as well as our recent reports of increased expression of cytokines in the prefrontal cortex in victims of suicide and in experimental animals sensitized and exposed to tree pollen. A relationship between changes in allergy symptom scores and changes in depression scores supports a state-level rather than only trait-level relationship, and thus lends optimism to future causality-testing interventional studies, which might then lead to novel preventative environmental interventions in mood disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.