ArticleGenetics and molecular biology2007
Evaluation of gene expression profiling in a mouse model of L-gulonolactone oxidase gene deficiency.
Article in Genetics and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.
- Critical evaluation of transcription factor Atf2 as a candidate modulator of alcohol preference in mouse and human populations.Genetics and molecular research : GMR · 2013Pooled it
- Multiple genome analyses reveal key genes in Vitamin C and Vitamin D synthesis and transport pathways are shared.Scientific reports · 2019Article
- Effect of fluorosis on liver cells of VC deficient and wild type mice.TheScientificWorldJournal · 2014Article
- Genome wide analysis of sex difference in gene expression profiles of bone formations using sfx mice and BXD RI strains.TheScientificWorldJournal · 2014Article
- Genome-wide gene expression profiles in antioxidant pathways and their potential sex differences and connections to vitamin C in mice.International journal of molecular sciences · 2013Article
- Pancreatic insulin release in vitamin C-deficient senescence marker protein-30/gluconolactonase knockout mice.Journal of clinical biochemistry and nutrition · 2012Article
- Differential gene expression between wild-type and Gulo-deficient mice supplied with vitamin C.Genetics and molecular biology · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Humans and guinea pigs are species which are unable to synthesize ascorbic acid (vitamin C) because, unlike rodents, they lack the enzyme L-gulonolactone oxidase (Gulo). Although the phenotype of lacking vitamin C in humans, named scurvy, has long been well known, information on the impact of lacking Gulo on the gene expression profiles of different tissues is still missing. This knowledge could improve our understanding of molecular pathways in which Gulo may be involved. Recently, we discovered a deletion that includes all 12 exons in the gene for Gulo in the sfx mouse, characterized by spontaneous bone fractures. We report here the initial analysis of the impact of the Gulo gene deletion on the murine gene expression profiles in the liver, femur and kidney.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.