ArticleThe Journal of cell biology2007
Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier.
Article in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
67 citing papers in PubMed, 144 citations in OpenAlex.
- Genetic legacy and recent cross of two ancient lineages underlie the rebound of the world's rarest primate.Science advances · 2026Article
- C. elegans epicuticlins define specific compartments in the apical extracellular matrix and function in wound repair.Development (Cambridge, England) · 2024Article
- Diminished γδ T Cells during Murine Allergic Skin Inflammation Is Mediated by IL-4 Signaling in Keratinocytes.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Dihydromyrcenol Modulates Involucrin Expression through the Akt Signaling Pathway.International journal of molecular sciences · 2024Article
- Targeting lymphoid-derived IL-17 signaling to delay skin aging.Nature aging · 2023Article
- Involucrin Modulates Vitamin D Receptor Activity in the Epidermis.The Journal of investigative dermatology · 2023Article
- Thermostable Proteins from HaCaT Keratinocytes Identify a Wide Breadth of Intrinsically Disordered Proteins and Candidates for Liquid-Liquid Phase Separation.International journal of molecular sciences · 2022Article
- MAB21L4 Deficiency Drives Squamous Cell Carcinoma via Activation of RET.Cancer research · 2022Article
- Loricrin at the Boundary between Inside and Outside.Biomolecules · 2022Review
- Loricrin and NRF2 Coordinate Cornification.JID innovations : skin science from molecules to population health · 2022Article
- γδ T Cells in Skin Inflammation.Critical reviews in immunology · 2022Review
- Identification of Biomarkers Associated With CD4Frontiers in immunology · 2022Article
- The Epidermis: Redox Governor of Health and Diseases.Antioxidants (Basel, Switzerland) · 2021Review
- Molecular Mechanisms of Eosinophilic Esophagitis.International journal of molecular sciences · 2021Review
- Desmoplakin and periplakin genetically and functionally contribute to eosinophilic esophagitis.Nature communications · 2021Observational
- Commensal-Related Changes in the Epidermal Barrier Function Lead to Alterations in the Benzo[mBio · 2021Article
- Article
- Unbound Corneocyte Lipid Envelopes in 12R-Lipoxygenase Deficiency Support a Specific Role in Lipid-Protein Cross-Linking.The American journal of pathology · 2021Article
- "Structural imprinting" of the cutaneous immune effector function.Tissue barriers · 2021Review
- Biomimetic and estrogenic fibers promote tissue repair in mice and human skin via estrogen receptor β.Biomaterials · 2020Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
The cornified envelope is assembled from transglutaminase cross-linked proteins and lipids in the outermost epidermal layers and is essential for skin barrier function. Involucrin, envoplakin, and periplakin form the protein scaffold on which the envelope assembles. To examine their combined function, we generated mice deficient in all three genes. The triple knockouts have delayed embryonic barrier formation and postnatal hyperkeratosis (abnormal accumulation of cornified cells) resulting from impaired desquamation. Cornified envelopes form but are ultrastructurally abnormal, with reduced lipid content and decreased mechanical integrity. Expression of proteases is reduced and the protease inhibitor, serpina1b, is highly upregulated, resulting in defective filaggrin processing and delayed degradation of desmoglein 1 and corneodesmosin. There is infiltration of CD4+ T cells and a reduction in resident gammadelta+ T cells, reminiscent of atopic dermatitis. Thus, combined loss of the cornified envelope proteins not only impairs the epidermal barrier, but also changes the composition of T cell subpopulations in the skin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.