ReviewThe Journal of cell biology2007
The expanding role of the ER translocon in membrane protein folding.
Review in The Journal of cell biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A diversified and segregated mRNA spliced-leader system in the parasitic Perkinsozoa.Open biology · 2022Article
- C-terminal tail length guides insertion and assembly of membrane proteins.The Journal of biological chemistry · 2020Article
- Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.Immunity · 2016Article
- Insight into the Exoproteome of the Tissue-Derived Trypomastigote form ofFrontiers in chemistry · 2016Article
- Article
- Positional editing of transmembrane domains during ion channel assembly.Journal of cell science · 2013Article
- Palmitoylated calnexin is a key component of the ribosome-translocon complex.The EMBO journal · 2012Article
- Mechanisms for quality control of misfolded transmembrane proteins.Biochimica et biophysica acta · 2012Review
- The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology.Physiological reviews · 2012Review
- An analysis of the transcriptome of Teladorsagia circumcincta: its biological and biotechnological implications.BMC genomics · 2012Article
- In silico secretome analysis approach for next generation sequencing transcriptomic data.BMC genomics · 2011Article
- Positive charges of translocating polypeptide chain retrieve an upstream marginal hydrophobic segment from the endoplasmic reticulum lumen to the translocon.Molecular biology of the cell · 2010Article
- Membrane protein folding makes the transition.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Secretome: clues into pathogen infection and clinical applications.Genome medicine · 2009Article
- Lipase maturation factor LMF1, membrane topology and interaction with lipase proteins in the endoplasmic reticulum.The Journal of biological chemistry · 2009Article
- Coordinated activation of the secretory pathway during notochord formation in the Xenopus embryo.Development (Cambridge, England) · 2009Article
- Insertion of short transmembrane helices by the Sec61 translocon.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Sequence-specific retention and regulated integration of a nascent membrane protein by the endoplasmic reticulum Sec61 translocon.Molecular biology of the cell · 2009Article
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1 author.
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No grant is acknowledged in the PubMed record.
Abstract
Eukaryotic polytopic membrane proteins are cotranslationally inserted into the ER membrane by a multisubunit protein-conducting channel called the Sec61 translocon. Although most major translocon components have been identified and reconstituted, their stoichiometry and functional organization remain unknown. This has led to speculative and sometimes conflicting models describing how multiple transmembrane (TM) segments might be oriented and integrated during nascent polytopic protein biogenesis. Kida et al. (see p. 1441 of this issue) shed new insight into this area by demonstrating that functional translocons exhibit a remarkable flexibility by simultaneously accommodating at least two hydrophilic translocating peptides that are separated by multiple hydrophobic TMs. These surprising findings support an expanded role for the translocon in membrane protein biogenesis and require reassessment of current views based on a single small functional pore.
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