ArticleThe Journal of general physiology2008
Disuse-induced preferential loss of the giant protein titin depresses muscle performance via abnormal sarcomeric organization.
Article in The Journal of general physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Effects of ageing on single muscle fibre contractile function following short-term immobilisation.The Journal of physiology · 2011Trial
- Stretch-shortening cycles mitigate single muscle fibre power deficits following a two-week immobilization of the rat hindlimb.Journal of muscle research and cell motility · 2026Article
- The Structural Adaptations That Mediate Mechanical Load-Induced Changes in Muscle Mass.Advances in experimental medicine and biology · 2025Review
- Editorial: State-of-the-art muscle physiology research: from single molecules and cells to living organisms.Frontiers in physiology · 2025Article
- Mice with R2509C-RYR1 mutation exhibit dysfunctional Ca2+ dynamics in primary skeletal myocytes.The Journal of general physiology · 2022Article
- Calpain-dependent degradation of cytoskeletal proteins as a key mechanism for a reduction in intrinsic passive stiffness of unloaded rat postural muscle.Pflugers Archiv : European journal of physiology · 2022Article
- Iron Supplementation Improves Skeletal Muscle Contractile Properties in Mice with CKD.Kidney360 · 2022Article
- Impact of chronic obstructive pulmonary disease on passive viscoelastic components of the musculoarticular system.Scientific reports · 2021Article
- Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome.Journal of clinical medicine · 2021Review
- Effects of high-pressure treatment on the structure and function of myofibrils.Biophysics and physicobiology · 2021Article
- Predominant synthesis of giant myofibrillar proteins in striated muscles of the long-tailed ground squirrel Urocitellus undulatus during interbout arousal.Scientific reports · 2020Article
- The problem with skeletal muscle series elasticity.BMC biomedical engineering · 2019Review
- Effect of L-Arginine on Titin Expression in Rat Soleus Muscle After Hindlimb Unloading.Frontiers in physiology · 2019Article
- Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers.American journal of respiratory and critical care medicine · 2018Article
- Analysis of Titin in Red and White Muscles: Crucial Role on Muscle Contractions Using a Fish Model.BioMed research international · 2018Article
- The role of calpains in ventilator-induced diaphragm atrophy.Intensive care medicine experimental · 2017Article
- Nuances of electrophoresis study of titin/connectin.Biophysical reviews · 2017Review
- Laryngeal Aerodynamics in Healthy Older Adults and Adults With Parkinson's Disease.Journal of speech, language, and hearing research : JSLHR · 2017Article
- Diaphragm abnormalities in heart failure and aging: mechanisms and integration of cardiovascular and respiratory pathophysiology.Heart failure reviews · 2017Review
- A Beetle Flight Muscle Displays Leg Muscle Microstructure.Biophysical journal · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Persistent muscle weakness due to disuse-associated skeletal muscle atrophy limits the quality of life for patients with various diseases and individuals who are confined to bed. Fibers from disused muscle exhibit a marked reduction in active force production, which can exacerbate motor function, coupled with the well-known loss of muscle quantity. Despite recent understanding of the signaling pathways leading to the quantity loss, the molecular mechanisms of the depressed qualitative performance still remain elusive. Here we show that long-term disuse causes preferential loss of the giant sarcomere protein titin, associated with changes in physiologic muscle function. Ca(2+) sensitivity of active force decreased following 6 wk of hindlimb immobilization in the soleus muscle of the rat, accompanied by a shift in the length-active force relationship to the shorter length side. Our analyses revealed marked changes in the disused sarcomere, with shortening of thick and thin filaments responsible for altered length dependence and expansion of interfilament lattice spacing leading to a reduction in Ca(2+) sensitivity. These results provide a novel view that disuse-induced preferential titin loss results in altered muscle function via abnormal sarcomeric organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.