ReviewPLoS pathogens2007
Nod-like receptors: cytosolic watchdogs for immunity against pathogens.
Review in PLoS pathogens, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Microbiome study of Murrah buffalo mastitis milk with emphasis on Acinetobacter species.BMC microbiology · 2025Article
- Speaking the host language: howMicrobiology (Reading, England) · 2023Review
- CARD9 Signaling, Inflammation, and Diseases.Frontiers in immunology · 2022Review
- Immune defenses of the mammary gland epithelium of dairy ruminants.Frontiers in immunology · 2022Review
- Modulation of Bovine Endometrial Cell Receptors and Signaling Pathways as a Nanotherapeutic Exploration against Dairy Cow Postpartum Endometritis.Animals : an open access journal from MDPI · 2021Review
- NLRC5 inhibits neointima formation following vascular injury and directly interacts with PPARγ.Nature communications · 2019Article
- Mannose-capped lipoarabinomannan in Mycobacterium tuberculosis pathogenesis.Pathogens and disease · 2018Review
- Cardiopulmonary Bypass Down-Regulates NOD Signaling and Inflammatory Response in Children with Congenital Heart Disease.PloS one · 2016Article
- Interleukin-18 increases TLR4 and mannose receptor expression and modulates cytokine production in human monocytes.Mediators of inflammation · 2015Article
- Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa.Journal of innate immunity · 2015Article
- Intracellular immunity: finding the enemy within--how cells recognize and respond to intracellular pathogens.Journal of leukocyte biology · 2014Article
- The role of bone marrow mesenchymal stem cells in the treatment of acute liver failure.BioMed research international · 2013Article
- Activation and regulation of interferon-β in immune responses.Immunologic research · 2012Review
- Small molecule tyrosine kinase inhibitors for the treatment of intestinal inflammation.Inflammatory bowel diseases · 2011Article
- Review: Toll-like receptors and NOD-like receptors in pulmonary antibacterial immunity.Innate immunity · 2010Review
- Respiratory syncytial virus impairs macrophage IFN-alpha/beta- and IFN-gamma-stimulated transcription by distinct mechanisms.American journal of respiratory cell and molecular biology · 2010Article
- The role of interleukin-18 in the metabolic syndrome.Cardiovascular diabetology · 2010Review
- Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner.Infection and immunity · 2010Article
- Restriction of Legionella pneumophila replication in macrophages requires concerted action of the transcriptional regulators Irf1 and Irf8 and nod-like receptors Naip5 and Nlrc4.Infection and immunity · 2009Article
- Nod1/Nod2-mediated recognition plays a critical role in induction of adaptive immunity to anthrax after aerosol exposure.Infection and immunity · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In mammals, tissue-specific sets of pattern-recognition molecules, including Nod-like receptors (NLR), enable concomitant and sequential detection of microbial-associated molecular patterns from both the extracellular and intracellular microenvironment. Repressing and de-repressing the cytosolic surveillance machinery contributes to vital immune homeostasis and protective responses within specific tissues. Conversely, defective biology of NLR drives the development of recurrent infectious, autoimmune and/or inflammatory diseases by failing to mount barrier functions against pathogens, to tolerate commensals, and/or to instruct the adaptive immune response against microbes. Better decoding microbial strategies that are evolved to circumvent NLR sensing will provide clues for the development of rational therapies aimed at curing and/or preventing common and emerging immunopathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.