ArticleJournal of the American Chemical Society2008
Toward beta-amino acid proteins: design, synthesis, and characterization of a fifteen kilodalton beta-peptide tetramer.
Article in Journal of the American Chemical Society, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 89 citations in OpenAlex.
- Programmable Helicity and Macrocycle Symmetry in β-Peptides via Site-Selective Thioamide Substitution.Journal of the American Chemical Society · 2025Article
- An abiotic, tetrameric, eight-helix bundle.Chemical science · 2023Article
- α,ε-Hybrid Peptide Foldamers: Self-Assembly of Peptide with Trans Carbon-Carbon Double Bonds in the Backbone and Its Saturated Analogue.ACS omega · 2018Article
- Foldamers wave to the ribosome.Nature chemistry · 2018Article
- Protein backbone engineering as a strategy to advance foldamers toward the frontier of protein-like tertiary structure.Organic & biomolecular chemistry · 2014Review
- Positive allostery in metal ion binding by a cooperatively folded β-peptide bundle.Journal of the American Chemical Society · 2014Article
- Comparison of backbone modification in protein β-sheets by α→γ residue replacement and α-residue methylation.Organic & biomolecular chemistry · 2014Article
- A rotamer library to enable modeling and design of peptoid foldamers.Journal of the American Chemical Society · 2014Article
- De novo design of self-assembling foldamers that inhibit heparin-protein interactions.ACS chemical biology · 2014Article
- Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron.Nature communications · 2014Article
- Slow folding-unfolding kinetics of an octameric β-peptide bundle.ACS chemical biology · 2014Article
- Protein-like tertiary folding behavior from heterogeneous backbones.Journal of the American Chemical Society · 2013Article
- Enzyme-free translation of DNA into sequence-defined synthetic polymers structurally unrelated to nucleic acids.Nature chemistry · 2013Article
- Serverification of molecular modeling applications: the Rosetta Online Server that Includes Everyone (ROSIE).PloS one · 2013Article
- Article
- Structural consequences of beta-amino acid preorganization in a self-assembling alpha/beta-peptide: fundamental studies of foldameric helix bundles.Journal of the American Chemical Society · 2010Article
- Asymmetric synthesis of enantiopure isoxazolidinone monomers for the synthesis of β-oligopeptides by chemoselective amide ligation.Tetrahedron · 2010Article
- Development of a rotamer library for use in beta-peptide foldamer computational design.Journal of the American Chemical Society · 2010Article
- Synthetic mimetics of protein secondary structure domains.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2010Review
- Detection and analysis of chimeric tertiary structures by backbone thioester exchange: packing of an alpha helix against an alpha/beta-peptide helix.Angewandte Chemie (International ed. in English) · 2010Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
A 28 residue "retro" beta-peptide has been designed to self-assemble as a tetramer, successfully recapitulating the octameric beta-peptide bundle complex Zwit-1F. Z28, the largest beta-peptide synthesized to date, was achieved in a linear, microwave-assisted synthesis in 19% isolated yield and high purity. Z28 forms the expected tetrameric complex and is more stable and cooperative in its folding than Zwit-1F. The successful design and synthesis of Z28 is an important step toward true beta-amino acid proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.