ReviewReviews in endocrine & metabolic disorders2008
Chronic pediatric inflammatory diseases: effects on bone.
Review in Reviews in endocrine & metabolic disorders, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06216704 (Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis), which is not on this map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Skeletal Health and Bone Marrow Composition in Adolescents With Cystic Fibrosis
Who cites it
11 citing papers in PubMed, 31 citations in OpenAlex.
- Pediatric pituitary neuroendocrine tumors-a 13-year experience in a tertiary center.Frontiers in oncology · 2023Article
- Bone impairment assessed by HR-pQCT in juvenile-onset systemic lupus erythematosus.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Is it necessary to screen for celiac disease in adult idiopathic osteoporosis?Gastroenterology and hepatology from bed to bench · 2015Article
- Pathological fractures in paediatric patients with inflammatory bowel disease.European journal of pediatrics · 2014Review
- Article
- Bone status in adults with early-onset juvenile idiopathic arthritis following 1-year anti-TNFα therapy and discontinuation of glucocorticoids.Rheumatology international · 2013Article
- Inflammatory bone loss: pathogenesis and therapeutic intervention.Nature reviews. Drug discovery · 2012Review
- The impact of inflammation on bone mass in children.Pediatric nephrology (Berlin, Germany) · 2011Review
- Assessment of bone remodelling in childhood-onset systemic lupus erythematosus.Rheumatology (Oxford, England) · 2011Article
- Secondary osteoporosis in patients with juvenile idiopathic arthritis.Journal of osteoporosis · 2011Article
- Smurf control in bone cells.Journal of cellular biochemistry · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
In children, chronic inflammatory diseases present a significant challenge to long-term skeletal health. These conditions are often associated with poor appetite and suboptimal overall nutrition, altered nutrient utilization, delayed puberty, inactivity, and reduced muscle mass, all of which can alter bone metabolism. In addition, bone cell activity is susceptible to the effects of the immune response that characterizes these diseases. Moreover, drugs used to treat these maladies, notably glucocorticoids, may have negative effects on bone formation and on linear growth in developing children. As a result, predicted peak bone mass may not be achieved, and fracture risk may be increased in the short term or in the future. Studies using primarily dual energy X-ray absorptiometry have documented that deficits in bone mass are common in these diseases. However, there are wide variations in the prevalence of low bone mass, largely due to differences in the characteristics of each study population. Recent studies provide insight into the pathogenesis of decreased bone mass in these conditions. In this paper we will provide an overview of the effects of chronic inflammatory conditions on bone mass in children. We will also present relevant data from adult patients, when pediatric data are scant or not available.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.