Trial reportObstetrics and gynecology2008
Return of chronic pelvic pain from endometriosis after raloxifene treatment: a randomized controlled trial.
Trial report in Obstetrics and gynecology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Safety and Effectiveness of Surgery With or Without Raloxifene (Evista (Trademark), Lilly) for the Treatment of Pelvic Pain Caused by Endometriosis
Pilot Study of the IL-1 Antagonist Anakinra for the Treatment of Endometriosis Related Symptoms
A Randomized Controlled Trial of a Nutritional Intervention for Endometriosis
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 134 citations in OpenAlex.
- Clinical and endocrine effects of pharmacological therapy in endometriosis: a systematic review and meta-analysis.Frontiers in endocrinology · 2026Pooled it
- Selective oestrogen receptor modulators (SERMs) for endometriosis.The Cochrane database of systematic reviews · 2021Pooled it
- Pooled it
- Human Endometriosis Tissue Microarray Reveals Site-specific Expression of Estrogen Receptors, Progesterone Receptor, and Ki67.Applied immunohistochemistry & molecular morphology : AIMM · 2019Trial
- Relating pelvic pain location to surgical findings of endometriosis.Obstetrics and gynecology · 2011Trial
- Hormonal Dysregulation and Neuroinflammation in Endometriosis: Convergent Druggable Pathways.Current issues in molecular biology · 2026Review
- Potential Roles of G Protein-Coupled Receptor 30 (GPR30) in Migraine Pathophysiology.Journal of pain research · 2026Review
- Anti-cancer Drugs in Endometriosis Management: Mechanisms and Therapeutic Potential.Current pharmaceutical design · 2026Review
- Progressively diminished estrogen signaling concordant with increased fibrosis in ectopic endometrium.Human reproduction open · 2025Article
- Treatment Strategies for Painful Pelvic Floor Conditions: A Focus on the Potential Benefits of Cannabidiol.Biomolecules · 2024Review
- Comparative Analysis of Medical Interventions to Alleviate Endometriosis-Related Pain: A Systematic Review and Network Meta-Analysis.Journal of clinical medicine · 2024Review
- Clinical Efficacy, Pharmacokinetics, and Safety of the Available Medical Options in the Treatment of Endometriosis-Related Pelvic Pain: A Scoping Review.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Hormonal treatments for endometriosis: The endocrine background.Reviews in endocrine & metabolic disorders · 2022Review
- New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments.International journal of molecular sciences · 2021Review
- Estrogen Receptors and Endometriosis.International journal of molecular sciences · 2020Review
- Progesterone and Estrogen Signaling in the Endometrium: What Goes Wrong in Endometriosis?International journal of molecular sciences · 2019Review
- Molecular Targets for Endometriosis Therapy: Where We Are and Where We Are Going?International journal of fertility & sterility · 2019Article
- Endometriosis and nuclear receptors.Human reproduction update · 2019Review
- Bazedoxifene/conjugated estrogens in combination with leuprolide for the treatment of endometriosis.Clinical case reports · 2018Article
- SR-16234, a Novel Selective Estrogen Receptor Modulator for Pain Symptoms with Endometriosis: An Open-label Clinical Trial.Yonago acta medica · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo evaluate whether 6 months of raloxifene was effective in treatment of chronic pelvic pain in women with endometriosis.
methodsWomen with chronic pelvic pain and no endometriosis treatment for 6 months underwent laparoscopy for excision of all lesions. Those with biopsy-proven endometriosis were randomly allocated to raloxifene (180 mg) or placebo daily. A second laparoscopy was performed at 2 years, or earlier, if pain returned. Return of pain was defined as 2 months of pain equal to or more severe than that at study entry. Menstrual cycles and adverse events were recorded. The log rank test was used to compare the time to return of pain by drug group. Analyses were done as intent-to-treat.
resultsA total of 127 of 158 women underwent surgery. Of these, 93 had biopsy-confirmed endometriosis and were randomly assigned to study treatment. Menstrual cycle length, pelvic pain severity, quality of life, bone mineral density, and adverse events did not differ between treatment groups. The Data Safety Monitoring Committee terminated the study early when the raloxifene group experienced pain (P=.03) and had second surgery (P=.016) significantly sooner than the placebo group. Interestingly, biopsy-proven endometriosis was not associated with return of pain (P=.6).
conclusionRaloxifene significantly shortened the time to return of chronic pelvic pain. Because recurrence of endometriosis lesions did not correlate with return of pain, other factors are implicated in pelvic pain. CLINICAL
trial registrationClinicalTrials.gov, www.cliicaltrials.gov, NCT00001848 LEVEL OF EVIDENCE: I.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.