ArticleThe American journal of pathology2008
A critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cells.
Article in The American journal of pathology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 66 citations in OpenAlex.
- The dual role of PCDH9 in tumors, neurological and developmental diseases.Medical oncology (Northwood, London, England) · 2025Review
- β2-Chimaerin Deficiency Favors Polyp Growth in the Colon of ApcMolecules (Basel, Switzerland) · 2025Article
- The Roles of RAC1 and RAC1B in Colorectal Cancer and Their Potential Contribution to Cetuximab Resistance.Cancers · 2024Review
- Proteomic Profiling of Chemotherapy Responses in FOLFOX-Resistant Colorectal Cancer Cells.International journal of molecular sciences · 2023Article
- PCDH9 suppresses melanoma proliferation and cell migration.Frontiers in oncology · 2022Article
- Oncogenic mutations on Rac1 affect global intrinsic dynamics underlying GTP and PAK1 binding.Biophysical journal · 2021Article
- The ZNF750-RAC1 axis as potential prognostic factor for breast cancer.Cell death discovery · 2020Article
- Rac1 activates non-oxidative pentose phosphate pathway to induce chemoresistance of breast cancer.Nature communications · 2020Article
- Expression profiling of microRNAs and isomiRs in conventional central chondrosarcoma.Cell death discovery · 2020Article
- IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models.PloS one · 2020Article
- Identification of potential key genes for HER-2 positive breast cancer based on bioinformatics analysis.Medicine · 2020Article
- Knockdown of RAC1 and VASP gene expression inhibits breast cancer cell migration.Oncology letters · 2018Article
- RAC1-GTP promotes epithelial-mesenchymal transition and invasion of colorectal cancer by activation of STAT3.Laboratory investigation; a journal of technical methods and pathology · 2018Article
- Somatic ERK activation during transit amplification is essential for maintaining the synchrony of germline divisions inOpen biology · 2018Article
- shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1.International journal of molecular medicine · 2018Article
- Discovery and characterization of small molecule Rac1 inhibitors.Oncotarget · 2017Article
- MIIP remodels Rac1-mediated cytoskeleton structure in suppression of endometrial cancer metastasis.Journal of hematology & oncology · 2016Article
- Deletion of epidermal Rac1 inhibits HPV-8 induced skin papilloma formation and facilitates HPV-8- and UV-light induced skin carcinogenesis.Oncotarget · 2016Article
- Cancer stem cells and cisplatin-resistant cells isolated from non-small-lung cancer cell lines constitute related cell populations.Cancer medicine · 2014Article
- Increased diacylglycerol kinase ζ expression in human metastatic colon cancer cells augments Rho GTPase activity and contributes to enhanced invasion.BMC cancer · 2014Article
Corrections and comments
- Erratum issuedBenitah, Salvador A [added]
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal adenocarcinoma is the second cause of cancer mortality in developed countries. Rac1 is a member of the family of Rho GTPases that regulates many intracellular signaling pathways, including those involved in tumorigenesis, invasion, and metastasis. We have investigated the role of Rac1 in colorectal tumor progression by genetic modification of the human colorectal adenocarcinoma cell line SW620 to either overexpress Rac1 or lack Rac1 expression. Tumor behavior was studied by orthotopic injection of stably modified cell lines into the cecal wall of athymic nude mice, a model that replicates the histopathological appearance and clinical behavior of human colorectal adenocarcinoma in humans. While overexpression of Rac1 resulted in an accelerated tumorigenic process, inducing a faster mortality rate, inhibition of Rac1 completely suppressed tumor formation. These results suggest that Rac1 plays a major role in colorectal adenocarcinoma progression. Finally, interference with Rac1 function may provide an important tool to block the malignant phenotype of colorectal adenocarcinoma cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.