Evidence map›Paper›PMID 18165013›Full record

ReviewTrends in biochemical sciences2008

Bacterial chemoreceptors: high-performance signaling in networked arrays.

Gerald L Hazelbauer, Joseph J Falke, John S Parkinson

Abstract readReview
In one paragraph

Review in Trends in biochemical sciences, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 371 papers.

0numbers the graph read from it
0cells of the map it votes in
371citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

371 citing papers in PubMed.

  1. ThemBio · 2026
    Article
  2. Article
  3. ZnbioRxiv : the preprint server for biology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Genomic Insights intoMicroorganisms · 2026
    Article
  10. Review
  11. Structure and signaling mechanism ofbioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Machine Learning Reveals Proteome-Encoded Growth Predictors ofbioRxiv : the preprint server for biology · 2025
    Article
  14. A chemoreceptor conformational equilibrium controlled by signaling inputs.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  15. Insights into Chemoreceptor MCP2201-Sensing D-Malate.International journal of molecular sciences · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

311 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Gerald L HazelbauerDepartment of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA. hazelbauerg@missouri.edu
Joseph J Falke
John S Parkinson

Funding

Intracellular Signaling by Bacterial ChemoreceptorsR01GM019559 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI JOHN S PARKINSON · 1985 to 2026
$12.3M
Molecular Studies of Chemoreception: Administrative Supplement for EquipmentR37GM029963 · NIGMS · UNIVERSITY OF MISSOURI-COLUMBIA · PI HAZELBAUER, GERALD L. · 2012 to 2021
$5.7M
MOLECULAR STUDIES OF CHEMORECEPTIONR01GM029963 · NIGMS · WASHINGTON STATE UNIVERSITY · PI HAZELBAUER, GERALD L. · 1985 to 2010
$4.2M
RECEPTORS &SIGNALING PROTEINS--DYNAMICS &ACTIVATIONR01GM040731 · NIGMS · UNIVERSITY OF COLORADO AT BOULDER · PI FALKE, JOSEPH J · 1988 to 2013
$3.4M
INTRACELLULAR SIGNALING BY BACTERIAL CHEMORECEPTORSR37GM019559 · NIGMS · UNIVERSITY OF UTAH · PI PARKINSON, JOHN S · 1992 to 2001
$806k
NIGMS NIH HHS GM19559NIGMS NIH HHS GM29963NIGMS NIH HHS GM40731NIGMS NIH HHS R01 GM019559NIGMS NIH HHS R01 GM029963NIGMS NIH HHS R01 GM040731NIGMS NIH HHS R37 GM019559NIGMS NIH HHS R37 GM029963
6 · The paper itself

Abstract

Chemoreceptors are crucial components in the bacterial sensory systems that mediate chemotaxis. Chemotactic responses exhibit exquisite sensitivity, extensive dynamic range and precise adaptation. The mechanisms that mediate these high-performance functions involve not only actions of individual proteins but also interactions among clusters of components, localized in extensive patches of thousands of molecules. Recently, these patches have been imaged in native cells, important features of chemoreceptor structure and on-off switching have been identified, and new insights have been gained into the structural basis and functional consequences of higher order interactions among sensory components. These new data suggest multiple levels of molecular interactions, each of which contribute specific functional features and together create a sophisticated signaling device.

Indexed as

Bacterial Physiological PhenomenaBacterial ProteinsChemoreceptor CellsChemotaxisDimerizationEscherichia coliEscherichia coli ProteinsMembrane ProteinsMethyl-Accepting Chemotaxis ProteinsModels, MolecularProtein Structure, TertiarySignal TransductionBacterial ProteinsCheW protein, E coliEscherichia coli ProteinsMembrane ProteinsMethyl-Accepting Chemotaxis ProteinsTsr protein, Bacteria

Identifiers

PMID18165013
PMCPMC2890293

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.