ReviewCancer letters2008
Field defects in progression to gastrointestinal tract cancers.
Review in Cancer letters, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed.
- Trial
- INHAND: Non-proliferative and proliferative lesions of fish - Chapter 3. Fish digestive system.Journal of toxicologic pathology · 2026Article
- The Role of Tumor Location on Endoscopic and Surgical Management of Malignant Colon Polyps.Annals of surgical oncology · 2024Article
- ASO Author Reflections: Malignant Colon Polyps-Is Tumor Laterality the New Black?Annals of surgical oncology · 2024Article
- Review
- Epigenome-Wide DNA Methylation Profiling of Normal Mucosa Reveals HLA-F Hypermethylation as a Biomarker Candidate for Serrated Polyposis Syndrome.The Journal of molecular diagnostics : JMD · 2022Article
- Exploiting unique features of the gut-brain interface to combat gastrointestinal cancer.The Journal of clinical investigation · 2021Review
- Review
- Epigenetic Field Cancerization in Gastric Cancer: microRNAs as Promising Biomarkers.Journal of Cancer · 2019Article
- Article
- Pancreatic Collision Tumor of Ductal Adenocarcinoma and Neuroendocrine Tumor.ACG case reports journal · 2018Article
- The genetics and molecular biology of colonic neoplasia: practical implications for the clinician.Current opinion in gastroenterology · 2017Review
- Field Cancerization in Sporadic Colon Cancer.Gut and liver · 2016Article
- Biliary multifocal chromosomal polysomy and cholangiocarcinoma in primary sclerosing cholangitis.The American journal of gastroenterology · 2015Article
- Copy number variations are progressively associated with the pathogenesis of colorectal cancer in ulcerative colitis.World journal of gastroenterology · 2015Article
- Epigenetic mechanisms in cancer: push and pull between kneaded erasers and fate writers.International journal of nanomedicine · 2015Review
- The renin-angiotensin system mediates EGF receptor-vitamin d receptor cross-talk in colitis-associated colon cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2014Article
- Assessment of nuclear nanomorphology marker to improve the detection of malignancy from bile duct biopsy specimens.American journal of clinical pathology · 2014Article
- Novel mechanistic insights into ectodomain shedding of EGFR Ligands Amphiregulin and TGF-α: impact on gastrointestinal cancers driven by secondary bile acids.Cancer research · 2014Article
- Field cancerization in the colon: a role for aberrant DNA methylation?Gastroenterology report · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
A field of defective tissue may represent a pre-malignant stage in progression to many cancers. However, field defects are often overlooked in studies of cancer progression through assuming tissue at some distance from the cancer is normal. We indicate, however, the generality of field defects in gastrointestinal cancers, including cancers of the oropharynx, esophagus, stomach, bile duct, pancreas, small intestine and colon/rectum. Common features of these field defects are reduced apoptosis competence, aberrant proliferation and genomic instability. These features are often associated with high bile acid exposure and may explain the association of dietary-related factors with cancer progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.