ArticleNeurochemistry international2008
Apoptosis induced by domoic acid in mouse cerebellar granule neurons involves activation of p38 and JNK MAP kinases.
Article in Neurochemistry international, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Marine Algal Toxins and Public Health: Insights from Shellfish and Fish, the Main Biological Vectors.Marine drugs · 2024Review
- 17-β Estradiol Rescued Immature Rat Brain against Glutamate-Induced Oxidative Stress and Neurodegeneration via Regulating Nrf2/HO-1 and MAP-Kinase Signaling Pathway.Antioxidants (Basel, Switzerland) · 2021Article
- Article
- Intermittent hypoxia training: Powerful, non-invasive cerebroprotection against ethanol withdrawal excitotoxicity.Respiratory physiology & neurobiology · 2018Review
- Distinguishing normal brain aging from the development of Alzheimer's disease: inflammation, insulin signaling and cognition.Neural regeneration research · 2018Review
- Neurodegenerative Diseases: Regenerative Mechanisms and Novel Therapeutic Approaches.Brain sciences · 2018Review
- Modulatory effects of Terminalia arjuna against domoic acid induced toxicity in Caco-2 cell line.Cytotechnology · 2017Article
- Cadmium impairs the survival and proliferation of cultured adult subventricular neural stem cells through activation of the JNK and p38 MAP kinases.Toxicology · 2017Article
- Recommendations from the INHAND Apoptosis/Necrosis Working Group.Toxicologic pathology · 2016Article
- Protective Effects of Otophylloside N on Pentylenetetrazol-Induced Neuronal Injury In vitro and In vivo.Frontiers in pharmacology · 2016Article
- Lead decreases cell survival, proliferation, and neuronal differentiation of primary cultured adult neural precursor cells through activation of the JNK and p38 MAP kinases.Toxicology in vitro : an international journal published in association with BIBRA · 2015Article
- P38 MAPK inhibition protects against glutamate neurotoxicity and modifies NMDA and AMPA receptor subunit expression.Journal of molecular neuroscience : MN · 2015Article
- Low-level domoic acid protects mouse cerebellar granule neurons from acute neurotoxicity: role of glutathione.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Article
- Intermittent hypoxia conditioning protects mitochondrial cytochrome c oxidase of rat cerebellum from ethanol withdrawal stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2012Article
- Ethanol withdrawal acts as an age-specific stressor to activate cerebellar p38 kinase.Neurobiology of aging · 2011Article
- Domoic acid as a developmental neurotoxin.Neurotoxicology · 2010Review
- Alcohol withdrawal and brain injuries: beyond classical mechanisms.Molecules (Basel, Switzerland) · 2010Review
- Muscarinic receptors prevent oxidative stress-mediated apoptosis induced by domoic acid in mouse cerebellar granule cells.Journal of neurochemistry · 2009Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
In mouse cerebellar granule neurons (CGNs) the marine neurotoxin domoic acid (DomA) induces neuronal cell death, either by apoptosis or by necrosis, depending on its concentration, with apoptotic damage predominating in response to low concentrations (100 nM). DomA-induced apoptosis is due to selective activation of AMPA/kainate receptors, and is mediated by DomA-induced oxidative stress, leading to mitochondrial dysfunction and activation of caspase-3. The p38 MAP kinase and the c-Jun NH2-terminal protein kinase (JNK) have been shown to be preferentially activated by oxidative stress. Here we report that DomA increases p38 MAP kinase and JNK phosphorylation, and that this effect is more pronounced in CGNs from Gclm (-/-) mice, which lack the modifier subunit of glutamate-cysteine ligase, have very low glutathione (GSH) levels, and are more sensitive to DomA-induced apoptosis than CGNs from wild-type mice. The increased phosphorylation of JNK and p38 kinase was paralleled by a decreased phosphorylation of Erk 1/2. The AMPA/kainate receptor antagonist NBQX, but not the NMDA receptor antagonist MK-801, prevents DomA-induced activation of p38 and JNK kinases. Several antioxidants (GSH ethyl ester, catalase and phenylbutylnitrone) also prevent DomA-induced phosphorylation of JNK and p38 MAP kinases. Inhibitors of p38 (SB203580) and of JNK (SP600125) antagonize DomA-induced apoptosis. These results indicate the importance of oxidative stress-activated JNK and p38 MAP kinase pathways in DomA-induced apoptosis in CGNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.