ArticleJournal of neuro-oncology2008
Proton magnetic resonance spectroscopy predicts proliferative activity in diffuse low-grade gliomas.
Article in Journal of neuro-oncology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Congress of neurological surgeons systematic review and evidence-based guidelines for the role of imaging in newly diagnosed WHO grade II diffuse glioma in adults: update.Journal of neuro-oncology · 2025Pooled it
- Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: correlation with tumor proliferative activity.Clinical nuclear medicine · 2012Trial
- Diagnostic and Therapeutic Issues in Glioma Using Imaging Data: The Challenge of Numerical Twinning.Journal of clinical medicine · 2023Review
- Interest of routine MR spectroscopic techniques for differential diagnosis between radionecrosis and progression of brain tumor lesions.European journal of radiology open · 2022Article
- Article
- Imaging practice in low-grade gliomas among European specialized centers and proposal for a minimum core of imaging.Journal of neuro-oncology · 2018Article
- [Magnetic resonance spectroscopy of brain tumors].Der Radiologe · 2017Article
- Current Management of Adult Diffuse Infiltrative Low Grade Gliomas.Current neurology and neuroscience reports · 2016Article
- Magnetic Resonance (MR) Metabolic Imaging in Glioma.Brain pathology (Zurich, Switzerland) · 2015Review
- New concepts in the management of diffuse low-grade glioma: Proposal of a multistage and individualized therapeutic approach.Neuro-oncology · 2015Review
- Convex-Envelope Based Automated Quantitative Approach to Multi-Voxel 1H-MRS Applied to Brain Tumor Analysis.PloS one · 2015Article
- Advanced MR imaging of gliomas: an update.BioMed research international · 2013Review
- Quantitative MR imaging and spectroscopy of brain tumours: a step forward?European radiology · 2012Article
- Magnetic resonance spectroscopic detection of lactate is predictive of a poor prognosis in patients with diffuse intrinsic pontine glioma.Neuro-oncology · 2011Article
- Predicting the outcome of grade II glioma treated with temozolomide using proton magnetic resonance spectroscopy.British journal of cancer · 2011Article
- Low-grade gliomas in adults.Current treatment options in neurology · 2008Article
- Comparison of multiple parameters obtained on 3T pulsed arterial spin-labeling, diffusion tensor imaging, and MRS and the Ki-67 labeling index in evaluating glioma grading.AJNR. American journal of neuroradiologyArticle
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the study was to investigate the ability of (1)HMRS to reflect proliferative activity of diffuse low-grade gliomas (WHO grade II). Between November 2002 and March 2007, a prospective study was performed on consecutive patients with suspected supratentorial hemispheric diffuse low-grade tumors. All the patients underwent MR examination using uniform procedures, and then surgical resection or biopsy within 2 weeks of the MR examination. Proliferative activity of the tumors was assessed by Ki-67 immunochemistry (Mb-1) on paraffin embedded tumor sections. Spectroscopic data was compared with Ki-67 labeling index and other histologic data such as histological subtype, cellular atypia, cellular density using univariate and multivariate analysis. 82 of 97 consecutive patients had histologically confirmed WHO grade 2 gliomas. Ki-67 proliferation index (PI) was correlated with specific spectral patterns: (1) low PI (<4%) was associated with increased Cho/Cr and absence of both free lipids or lactates; (2) intermediate PI (4-8%) was associated with resonance of lactates; and (3) high PI (>8%) was characterized by a resonance of free lipids. On multivariate analysis, resonance of lactates and resonance of free lipids appeared as independent predictors of intermediate PI (P < 0.001) and high PI (P < 0.001), respectively; moreover, free lipids resonance was correlated with cellular atypia (P < 0.05). This study suggests that (1)HMRS is a reliable tool to evaluate the proliferation activity of WHO grade 2 glioma and to identify potentially more aggressive clinical behavior.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.