ReviewAmerican journal of physiology. Lung cellular and molecular physiology2008
Amiloride-insensitive Na+ and fluid absorption in the mammalian distal lung.
Review in American journal of physiology. Lung cellular and molecular physiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Personalized CFTR Modulator Therapy forInternational journal of molecular sciences · 2023Article
- Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.iScience · 2019Article
- Influence of Inhaled Amiloride on Lung Fluid Clearance in Response to Normobaric Hypoxia in Healthy Individuals.High altitude medicine & biology · 2017Article
- Alveolar nonselective channels are ASIC1a/α-ENaC channels and contribute to AFC.American journal of physiology. Lung cellular and molecular physiology · 2017Article
- Involvement of Cytokines in the Pathogenesis of Salt and Water Imbalance in Congestive Heart Failure.Frontiers in immunology · 2017Article
- Airway surface liquid volume expansion induces rapid changes in amiloride-sensitive Na+ transport across upper airway epithelium-Implications concerning the resolution of pulmonary edema.Physiological reports · 2015Article
- Prolactin stimulates sodium and chloride ion channels in A6 renal epithelial cells.American journal of physiology. Renal physiology · 2015Article
- Unimpaired postnatal respiratory adaptation in a preterm human infant with a homozygous ENaC-α unit loss-of-function mutation.Journal of perinatology : official journal of the California Perinatal Association · 2011Article
- Clinical implication of lung fluid balance in the perinatal period.Journal of perinatology : official journal of the California Perinatal Association · 2011Review
- Nasal potential difference to detect Na+ channel dysfunction in acute lung injury.American journal of physiology. Lung cellular and molecular physiology · 2011Review
- Amiloride-sensitive sodium channels and pulmonary edema.Pulmonary medicine · 2011Article
- Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.The Journal of biological chemistry · 2009Article
- Some assembly required: putting the epithelial sodium channel together.The Journal of biological chemistry · 2008Review
- The porcine lung as a potential model for cystic fibrosis.American journal of physiology. Lung cellular and molecular physiology · 2008Review
- Reduction in systemic epithelial ion transport in septicemia-related pulmonary edema due to changes in amiloride-insensitive sodium transport?American journal of physiology. Lung cellular and molecular physiology · 2008Article
- Role of submembranous actin cytoskeleton in regulation of non-voltage-gated sodium channels.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ability of the distal lung epithelia to actively transport Na+, with Cl- and water following, from the alveolar spaces inversely correlates with morbidity and mortality of infants, children, and adults with alveolar pulmonary edema. It is now recognized, in contrast to many other Na+ transporting epithelia, that at least half of this active transport is not sensitive to amiloride, which inhibits the epithelial Na+ channel. This paper reviews amiloride-insensitive Na+ and fluid transport in the mammalian distal lung unit under basal conditions and speculates on potential explanations for this amiloride-insensitive transport. It also provides new information, using primary cultures of rat fetal distal lung epithelia and alveolar type II cells grown under submersion and air-liquid interface culture conditions, regarding putative blockers of this transport.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.