ArticleMolecular biology of the cell2008
The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans.
Article in Molecular biology of the cell, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
46 citing papers in PubMed, 62 citations in OpenAlex.
- Genetic and environmental control of parasexual reproduction in the pathogenicMicrobiology and molecular biology reviews : MMBR · 2025Review
- White-opaque switching inMicrobiology and molecular biology reviews : MMBR · 2024Review
- Activation of Cph1 causes ß(1,3)-glucan unmasking in Candida albicans and attenuates virulence in mice in a neutrophil-dependent manner.PLoS pathogens · 2021Article
- Unraveling HowJournal of fungi (Basel, Switzerland) · 2020Review
- Article
- MAP Kinase Regulation of themSphere · 2019Article
- Plasticity of Candida albicans Biofilms.Microbiology and molecular biology reviews : MMBR · 2016Review
- Binding Sites in the EFG1 Promoter for Transcription Factors in a Proposed Regulatory Network: A Functional Analysis in the White and Opaque Phases of Candida albicans.G3 (Bethesda, Md.) · 2016Article
- Comparison of Switching and Biofilm Formation between MTL-Homozygous Strains of Candida albicans and Candida dubliniensis.Eukaryotic cell · 2015Article
- Article
- pH Regulates White-Opaque Switching and Sexual Mating in Candida albicans.Eukaryotic cell · 2015Article
- Candida albicans Biofilm Development and Its Genetic Control.Microbiology spectrum · 2015Article
- Role of Tec1 in the development, architecture, and integrity of sexual biofilms of Candida albicans.Eukaryotic cell · 2015Article
- White cells facilitate opposite- and same-sex mating of opaque cells in Candida albicans.PLoS genetics · 2014Article
- Sexual reproduction of human fungal pathogens.Cold Spring Harbor perspectives in medicine · 2014Review
- Sexual biofilm formation in Candida tropicalis opaque cells.Molecular microbiology · 2014Article
- The role of phenotypic switching in the basic biology and pathogenesis of Candida albicans.Journal of oral microbiology · 2014Review
- Unisexual reproduction.Advances in genetics · 2014Review
- Impact of environmental conditions on the form and function of Candida albicans biofilms.Eukaryotic cell · 2013Article
- Sensing of the microbial neighborhood by Candida albicans.PLoS pathogens · 2013Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Candida albicans must undergo a switch from white to opaque to mate. Opaque cells then release mating type-specific pheromones that induce mating responses in opaque cells. Uniquely in C. albicans, the same pheromones induce mating-incompetent white cells to become cohesive, form an adhesive basal layer of cells on a surface, and then generate a thicker biofilm that, in vitro, facilitates mating between minority opaque cells. Through mutant analysis, it is demonstrated that the pathways regulating the white and opaque cell responses to the same pheromone share the same upstream components, including receptors, heterotrimeric G protein, and mitogen-activated protein kinase cascade, but they use different downstream transcription factors that regulate the expression of genes specific to the alternative responses. This configuration, although common in higher, multicellular systems, is not common in fungi, and it has not been reported in Saccharomyces cerevisiae. The implications in the evolution of multicellularity in higher eukaryotes are discussed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.