ArticleProceedings of the National Academy of Sciences of the United States of America2008
Retinal progenitor cells can produce restricted subsets of horizontal cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 86 citations in OpenAlex.
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- Sphingosine-1-phosphate signaling regulates the ability of Müller glia to become neurogenic, proliferating progenitor-like cells.bioRxiv : the preprint server for biology · 2025Article
- Murine Retina Outer Plexiform Layer Development and Transcriptome Analysis of Pre-Synapses in Photoreceptors.Life (Basel, Switzerland) · 2024Article
- Arl2 GTPase associates with the centrosomal protein Cdk5rap2 to regulate cortical development via microtubule organization.PLoS biology · 2024Article
- Lineage motifs: developmental modules for control of cell type proportions.bioRxiv : the preprint server for biology · 2023Article
- Early cis-regulatory events in the formation of retinal horizontal cells.Developmental biology · 2021Article
- A defined subset of clonal retinal stem cell spheres is biased to RPE differentiation.iScience · 2021Article
- Different lineage contexts direct common pro-neural factors to specify distinct retinal cell subtypes.The Journal of cell biology · 2020Article
- Direct Readout of Neural Stem Cell Transgenesis with an Integration-Coupled Gene Expression Switch.Neuron · 2020Article
- Cis-regulatory analysis of Onecut1 expression in fate-restricted retinal progenitor cells.Neural development · 2020Article
- Wiring the Binocular Visual Pathways.International journal of molecular sciences · 2019Review
- Lineage tracing analysis of cone photoreceptor associated cis-regulatory elements in the developing chicken retina.Scientific reports · 2019Article
- Quantitative analysis of the ThrbCRM1-centered gene regulatory network.Biology open · 2019Article
- Regenerative potential of mouse embryonic stem cell-derived PDGFRαWorld journal of stem cells · 2019Article
- Fate-restricted retinal progenitor cells adopt a molecular profile and spatial position distinct from multipotent progenitor cells.Developmental biology · 2018Article
- Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.Stem cell reports · 2017Article
- Visualization of herpes simplex virus type 1 virions using fluorescent colors.Journal of virological methods · 2017Article
- Neuronal Migration and Lamination in the Vertebrate Retina.Frontiers in neuroscience · 2017Review
- Single-cell analysis of the fate of c-kit-positive bone marrow cells.NPJ Regenerative medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Retinal progenitor cells have been shown to be multipotent throughout development. Similarly, many other structures of the developing central nervous system have been found to contain multipotent progenitor cells. Previous lineage studies did not address whether these multipotent progenitor cells were biased in their production of neuronal subtypes. This question is of interest because subtypes are the basis of distinct types of circuits. Here, lentivirus-mediated gene transfer was used to mark single retinal progenitor cells in vivo, and the different subtypes of horizontal cells (HCs) in each clone were quantified. Clones with two HCs consistently contained a single HC subtype, a pair of either H1 or H3 cells. This suggests that a multipotent progenitor cell produces a mitotic cell fated to make a terminal division that produces two HCs of only one subtype. This bias in production of one HC subtype suggests a previously undescribed mechanism of cell fate determination in at least a subset of retinal cells that involves decisions made by mitotic cells that are inherited in a symmetric manner by both neuronal daughter cells.
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