ArticleDiabetes2008
Evidence of interaction between PPARG2 and HNF4A contributing to variation in insulin sensitivity in Mexican Americans.
Article in Diabetes, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- A Comprehensive Analysis of Common and Rare Variants to Identify Adiposity Loci in Hispanic Americans: The IRAS Family Study (IRASFS).PloS one · 2015Pooled it
- Genetic variants and the risk of gestational diabetes mellitus: a systematic review.Human reproduction updatePooled it
- Exploring the Role of Glycine Metabolism in Coronary Artery Disease: Insights from Human Genetics and Mouse Models.Nutrients · 2025Article
- A NovelFrontiers in pediatrics · 2020Article
- A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile.The British journal of nutrition · 2018Article
- Exome Sequencing Identifies Genetic Variants Associated with Circulating Lipid Levels in Mexican Americans: The Insulin Resistance Atherosclerosis Family Study (IRASFS).Scientific reports · 2018Article
- Longitudinal Increases in Adiposity Contribute to Worsening Adipokine Profile over Time in Mexican Americans.Obesity (Silver Spring, Md.) · 2018Article
- Association of weight gain and fifteen adipokines with declining beta-cell function in Mexican Americans.PloS one · 2018Article
- Association between PPAR-γ2 Pro12Ala genotype and insulin resistance is modified by circulating lipids in Mexican children.Scientific reports · 2016Article
- Ambient Air Pollutants Have Adverse Effects on Insulin and Glucose Homeostasis in Mexican Americans.Diabetes care · 2016Article
- Relationship between expression and methylation of obesity-related genes in children.Mutagenesis · 2015Article
- Variation in PPARG is associated with longitudinal change in insulin resistance in Mexican Americans at risk for type 2 diabetes.The Journal of clinical endocrinology and metabolism · 2015Article
- Article
- Gestational diabetes mellitus, maternal obesity, and adiposity in offspring.The Journal of pediatrics · 2014Article
- A bioinformatics approach reveals novel interactions of the OVOL transcription factors in the regulation of epithelial - mesenchymal cell reprogramming and cancer progression.BMC systems biology · 2014Article
- Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus.Diabetologia · 2013Article
- High-fat diet is associated with obesity-mediated insulin resistance and β-cell dysfunction in Mexican Americans.The Journal of nutrition · 2013Article
- Self-reported physical activity is associated with β-cell function in Mexican American adults.Diabetes care · 2013Article
- Hyperinsulinaemic hypoglycaemia:genetic mechanisms, diagnosis and management.Journal of clinical research in pediatric endocrinology · 2012Review
- Health disparities in endocrine disorders: biological, clinical, and nonclinical factors--an Endocrine Society scientific statement.The Journal of clinical endocrinology and metabolism · 2012Article
Corrections and comments
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Authors and funding
15 authors at 7 institutions in 1 country.
Funding
Abstract
objectiveWe hypothesized that interaction between PPARG2 Pro12Ala and variants in the promoter region of HNF4A are associated with type 2 diabetes-related quantitative traits in Mexican-American families of a proband with previous gestational diabetes. RESEARCH DESIGN AND
methodsThe BetaGene project genotyped PPARG2 Pro12Ala and nine HNF4A single nucleotide polymorphisms (SNPs) in 473 individuals in 89 families. Members of the proband generation had fasting glucose <126 mg/dl and were phenotyped by oral and intravenous glucose tolerance tests.
resultsNeither PPARG2 Pro12Ala nor any of the nine HNF4A SNPs were independently associated with type 2 diabetes-related quantitative traits. However, the interaction between PPARG2 Pro12Ala and HNF4A rs2144908 was significantly associated with both insulin sensitivity (S(I)) (Bonferroni P = 0.0006) and 2-h insulin (Bonferroni P = 0.039). Subjects with at least one PPARG2 Ala allele and homozygous for the HNF4A rs2144908 A allele had 40% higher S(I) compared with individuals with at least one G allele. S(I) did not vary by rs2144908 genotype among PPARG2 Pro/Pro. The interaction result for S(I) was replicated by the Insulin Resistance Atherosclerosis Family Study (P = 0.018) in their San Antonio sample (n = 484) where subjects with at least one PPARG2 Ala allele and homozygous for the HNF4A rs2144908 A allele had a 29% higher S(I) compared with individuals with at least one G allele. However, the interaction was not replicated in their San Luis Valley sample (n = 496; P = 0.401).
conclusionsTogether, these results suggest that variation in PPARG2 and HNF4A may interact to regulate insulin sensitivity in Mexican Americans at risk for type 2 diabetes.
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