ReviewPhysiological genomics2008
Methods and approaches for the comprehensive characterization and quantification of cellular proteomes using mass spectrometry.
Review in Physiological genomics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed.
- Bioinformatics strategies and biomarker refinement using high-throughput transcriptome data in transplantation.Frontiers in bioinformatics · 2026Article
- Application of Proteomics Technology Based on LC-MS Combined with Western Blotting and Co-IP in Antiviral Innate Immunity.Methods in molecular biology (Clifton, N.J.) · 2025Article
- How Can Proteomics Help to Elucidate the Pathophysiological Crosstalk in Muscular Dystrophy and Associated Multi-System Dysfunction?Proteomes · 2024Article
- The Concept of Immunogenetics.Advances in experimental medicine and biology · 2022Article
- Quantitative mass spectrometry of urinary biomarkers.Journal of integrated OMICS · 2014Article
- Quantitative proteomics to study carbapenem resistance in Acinetobacter baumannii.Frontiers in microbiology · 2014Review
- Proteomic analysis of seminal fluid from men exhibiting oxidative stress.Reproductive biology and endocrinology : RB&E · 2013Article
- Functional proteomic analysis of seminal plasma proteins in men with various semen parameters.Reproductive biology and endocrinology : RB&E · 2013Article
- Quantitative characterization of changes in the cardiac mitochondrial proteome during anesthetic preconditioning and ischemia.Physiological genomics · 2013Article
- Mass spectrometry-based proteomics in molecular diagnostics: discovery of cancer biomarkers using tissue culture.BioMed research international · 2013Review
- Mitochondrial proteomic analysis reveals deficiencies in oxygen utilization in medullary thick ascending limb of Henle in the Dahl salt-sensitive rat.Physiological genomics · 2012Article
- Characterization of breast cancer interstitial fluids by TmT labeling, LTQ-Orbitrap Velos mass spectrometry, and pathway analysis.Journal of proteome research · 2012Article
- Sequential abundant ion fragmentation analysis (SAIFA): an alternative approach for phosphopeptide identification using an ion trap mass spectrometer.Analytical biochemistry · 2011Article
- Fluorescence two-dimensional difference gel electrophoresis for biomaterial applications.Journal of the Royal Society, Interface · 2010Review
- Platelet proteome changes associated with diabetes and during platelet storage for transfusion.Journal of proteome research · 2009Article
- Systematic mapping of posttranslational modifications in human estrogen receptor-alpha with emphasis on novel phosphorylation sites.Molecular & cellular proteomics : MCP · 2009Article
- Multidimensional protein fractionation using ProteomeLab PF 2D for profiling amyotrophic lateral sclerosis immunity: A preliminary report.Proteome science · 2008Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Proteomics has been proposed as one of the key technologies in the postgenomic era. So far, however, the comprehensive analysis of cellular proteomes has been a challenge because of the dynamic nature and complexity of the multitude of proteins in cells and tissues. Various approaches have been established for the analyses of proteins in a cell at a given state, and mass spectrometry (MS) has proven to be an efficient and versatile tool. MS-based proteomics approaches have significantly improved beyond the initial identification of proteins to comprehensive characterization and quantification of proteomes and their posttranslational modifications (PTMs). Despite these advances, there is still ongoing development of new technologies to profile and analyze cellular proteomes more completely and efficiently. In this review, we focus on MS-based techniques, describe basic approaches for MS-based profiling of cellular proteomes and analysis methods to identify proteins in complex mixtures, and discuss the different approaches for quantitative proteome analysis. Finally, we briefly discuss novel developments for the analysis of PTMs. Altered levels of PTM, sometimes in the absence of protein expression changes, are often linked to cellular responses and disease states, and the comprehensive analysis of cellular proteome would not be complete without the identification and quantification of the extent of PTMs of proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.